维生素D受体基因、血浆25-羟基维生素D的变异与经前症状风险

Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms.

作者信息

Jarosz Alicia C, Noori Daniel, Zeitoun Tara, Garcia-Bailo Bibiana, El-Sohemy Ahmed

机构信息

Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Ontario, M5S 1A8, Toronto, Canada.

出版信息

Genes Nutr. 2021 Sep 22;16(1):15. doi: 10.1186/s12263-021-00696-2.

DOI:10.1186/s12263-021-00696-2

PMID:34551710

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8459465/

Abstract

BACKGROUND

Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR).

OBJECTIVE

To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype.

METHODS

Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA was obtained from blood samples to genotype for a common VDR single nucleotide variant, rs796858. Using logistic regression, odds of experiencing PMSx were compared between vitamin D-sufficient and insufficient women, stratified by genotype.

RESULTS

Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue (OR, 2.53; 95% CI, 1.40, 4.56) and nausea (OR, 2.44; 95% CI, 1.00, 5.95). Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue (OR, 0.44; 95% CI, 0.20, 0.97) and increased appetite (OR, 0.48; 95% CI, 0.22, 1.04). Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype (OR, 1.78; 95% CI, 1.03, 3.07). VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039).

CONCLUSION

We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype.

摘要

背景

在一些但并非所有研究中，维生素D状态与几种经前症状（PMSx）的存在和严重程度有关。研究结果之间的不一致可能是由于维生素D受体（VDR）中未考虑的基因变异所致。

目的

确定维生素D状态与个体PMSx之间的关联是否受VDR基因型影响。

方法

来自多伦多营养基因组学与健康研究的716名20 - 29岁女性提供了血浆样本，并完成了一份关于15种常见PMSx的存在和严重程度的问卷。测量血浆25 - 羟基维生素D（25(OH)D）浓度，并将参与者分为维生素D状态充足（≥50 nmol/L）和不足（< 50 nmol/L）两组。从血液样本中获取DNA，对常见的VDR单核苷酸变异rs796858进行基因分型。使用逻辑回归，比较维生素D充足和不足的女性之间出现PMSx的几率，并按基因型分层。

结果

在CC纯合子中，维生素D状态不足与经前疲劳（比值比[OR]，2.53；95%置信区间[CI]，1.40，4.56）和恶心（OR，2.44；95% CI，1.00，5.95）的较高几率相关。在TT纯合子中，维生素D状态不足与疲劳（OR，0.44；95% CI，0.20，0.97）和食欲增加（OR，0.48；95% CI，0.22，1.04）的较低几率相关。维生素D状态不足与CT基因型女性食欲增加的较高几率相关（OR，1.78；95% CI，1.03，3.07）。VDR基因型改变了维生素D状态与以下PMSx之间的关联：食欲增加（交互作用p = 0.027）、疲劳（交互作用p = 0.016）和恶心（交互作用p = 0.039）。