Division of Cardiology, 1st Department of Medicine, Medical School, University of Pecs, 7624 Pecs, Hungary.
Szentágothai Research Centre, University of Pecs, 7624 Pecs, Hungary.
Int J Mol Sci. 2021 Sep 21;22(18):10152. doi: 10.3390/ijms221810152.
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective effects of natural polyphenols such as resveratrol (3,5,4-trihydroxystilbene) have been extensively investigated throughout recent decades. Many studies of RES have focused on its favorable effects on pathological conditions related to cardiovascular diseases and their risk factors. The aim of this review was to summarize the wide beneficial effects of resveratrol on the cardiovascular system, including signal transduction pathways of cell longevity, energy metabolism of cardiomyocytes or cardiac remodeling, and its anti-inflammatory and antioxidant properties. In addition, this paper discusses the significant preclinical and human clinical trials of recent years with resveratrol on cardiovascular system. Finally, we present a short overview of antiviral and anti-inflammatory properties and possible future perspectives on RES against COVID-19 in cardiovascular diseases.
心血管疾病是全球范围内的主要死亡原因。近年来，人们广泛研究了天然多酚如白藜芦醇（3,5,4-三羟基二苯乙烯）对心脏的保护作用。许多关于 RES 的研究都集中在其对与心血管疾病及其危险因素相关的病理状况的有利影响上。本综述的目的是总结白藜芦醇对心血管系统的广泛有益作用，包括细胞长寿的信号转导途径、心肌细胞或心脏重构的能量代谢，以及其抗炎和抗氧化特性。此外，本文还讨论了近年来有关白藜芦醇对心血管系统的重要临床前和人体临床试验。最后，我们简要概述了白藜芦醇在对抗 COVID-19 中的抗病毒和抗炎特性以及可能的未来前景。
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