利福平耐药结核病患者炎症细胞因子与校正QT间期的相关性
Correlation of inflammatory cytokines on corrected QT interval in rifampicin-resistant tuberculosis patients.
作者信息
Kusmiati Tutik, Mertaniasih Ni Made, Eko Putranto Johanes Nugroho, Suprapti Budi, Luthfah Nadya, Koesoemoprodjo Winariani, Sari Aryani Prawita
机构信息
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
出版信息
Ann Med Surg (Lond). 2021 Sep 14;70:102862. doi: 10.1016/j.amsu.2021.102862. eCollection 2021 Oct.
BACKGROUND
The cases of Rifampicin-Resistant Tuberculosis (RR-TB) in our country have increased every year and RR-TB deaths are thought to be caused by prolongation of the QTc interval due to side effects of anti-tuberculosis drugs. Thus, cytokines are needed to be used as early markers of prolongation of the QTc interval in RR-TB patients.
OBJECTIVE
This study aims to analyze the correlation of inflammatory cytokines on QTc interval in RR-TB patients who received shorter regimens.
METHODS
This study uses a case-control study with a time series conducted in the period September 2019 to February 2020 in one of the referral hospitals for Tuberculosis in Indonesia. Cytokines levels from blood samples were measured using the ELISA method, while QTc intervals were automatically recorded using an electrocardiography machine. The statistical analysis used was the Chi-square test, Man Whitney test, Independence -test, and Spearman-rank test with < 0.05.
RESULTS
There was no significant correlation between inflammatory cytokines and QTc prolongation in intensive phase which TNF-α value (6.8 pg/ml; = 0.207; = 0.281), IL-1β (20.13 pg/ml; = 0.128; = 0.509), and IL-6 (43.17 pg/ml; = -0.028; = 0.886). Meanwhile, in the continuation phase, the values for TNF-α (4.79 pg/ml; = 0.046; = 0.865), IL-1β (7.42 pg/ml; r = -0.223; = 0.406), and IL- 6 (40.61 pg/ml; = -0.147; = 0.586).
CONCLUSION
inflammatory cytokines (TNF-α, IL-1β, and IL-6) cannot be used to identify QTc interval prolongation in RR-TB patients who received shorter regimens.
背景
我国耐利福平结核病（RR-TB）病例逐年增加，RR-TB死亡被认为是由抗结核药物副作用导致的QTc间期延长所致。因此，需要细胞因子作为RR-TB患者QTc间期延长的早期标志物。
目的
本研究旨在分析接受短程治疗方案的RR-TB患者中炎性细胞因子与QTc间期的相关性。
方法
本研究采用病例对照研究和时间序列研究，于2019年9月至2020年2月在印度尼西亚一家结核病转诊医院进行。采用ELISA法检测血样中的细胞因子水平，同时使用心电图机自动记录QTc间期。所采用的统计分析方法为卡方检验、曼-惠特尼检验、独立性检验和Spearman秩检验，P<0.05。
结果
在强化期，炎性细胞因子与QTc延长之间无显著相关性，其中TNF-α值为（6.8 pg/ml；P=0.207；r=0.281），IL-1β为（20.13 pg/ml；P=0.128；r=0.5），IL-6为（43.17 pg/ml；P=-0.028；r=0.886）。同时，在继续期，TNF-α值为（4.79 pg/ml；P=0.046；r=0.865），IL-1β为（7.42 pg/ml；r=-0.223；P=0.406），IL-6为（40.61 pg/ml；P=-0.147；r=0.586）。
结论
炎性细胞因子（TNF-α、IL-1β和IL-6）不能用于识别接受短程治疗方案的RR-TB患者的QTc间期延长。
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