欧洲老年人肌肉减少症工作组原始共识与修订共识的比较：社区居住老年人的概率性横断面调查。

Comparison between Original and Reviewed Consensus of European Working Group on Sarcopenia in Older People: A Probabilistic Cross-Sectional Survey among Community-Dwelling Older People.

机构信息

Body Composition Lab, Faculty of Public Health and Nutrition, Autonomous University of Nuevo Leon, Monterrey, Mexico.

Population Nutrition Laboratory, Faculty of Public Health and Nutrition, Autonomous University of Nuevo León, Monterrey, Mexico.

出版信息

Gerontology. 2022;68(8):869-876. doi: 10.1159/000519304. Epub 2021 Sep 30.

DOI:10.1159/000519304

PMID:34592734

Abstract

INTRODUCTION

The European Working Group on Sarcopenia in Older People (EWGSOP) published a consensus on sarcopenia in 2010 and updated it in 2019 (EWGSOP2) which included the use of specific cut-off points. The aim was to assess how much prevalence of sarcopenia differed between EWGSOP2 and EWGSOP, as well as the use of specific cut-off points to assess differences in presarcopenia versus probable sarcopenia.

METHODS

Observational, transversal, and comparative study (n = 1,283 older adults; 57% women). Anthropometrics and handgrip strength were measured, and appendicular skeletal muscle mass equation was defined. Conceptual and methodological definitions of EWGSOP and EWGSOP2 consensus were applied to calculate prevalence of presarcopenia, probable sarcopenia, and sarcopenia.

RESULTS

Using cut-off points recommended for European population, prevalence of sarcopenia with EWGSOP2 was lower (-6.6%; p < 0.001) than EWGSOP. The prevalence of probable sarcopenia (EWGSOP2) was higher (+7.8%; p < 0.001) than EWGSOP presarcopenia. The agreement between EGWGSOP and EWGSOP2 was moderated (K = 0.45; IC = 0.40-0.51). Using specific-population cut-off points for muscle strength and appendicular muscle mass, the prevalence of probable sarcopenia with EWGSOP2 was higher (46.5%; p < 0.001) than EWGSOP (1.8%). The agreement between EGWGSOP and EWGSOP2 was moderated (K = 0.48; IC = 0.42-0.52).

CONCLUSION

The new EWGSOP2 consensus underestimates the prevalence of sarcopenia, compared with EWGSOP using conventional cut-off points. The prevalence of presarcopenia with EWGSOP (low muscle mass) was lower than probable sarcopenia (low muscle strength) with the new EWGSOP2. In both cases, agreements between EWGSOP2 and EWGSOP were moderated. Discrepancies between the original and new consensus have implications on the primary health setting for identifying old and new cases for prevention and treatment.

摘要

简介

欧洲老年人肌肉减少症工作组（EWGSOP）于 2010 年发布了肌肉减少症共识，并于 2019 年进行了更新（EWGSOP2），其中包括使用特定的截断值。目的是评估 EWGSOP2 与 EWGSOP 之间肌肉减少症的患病率差异，以及使用特定的截断值评估前肌肉减少症与可能的肌肉减少症之间的差异。

方法

观察性、横断面和比较研究（n=1283 名老年人；57%为女性）。测量人体测量学和握力，并定义四肢骨骼肌质量方程。应用 EWGSOP 和 EWGSOP2 共识的概念和方法定义来计算前肌肉减少症、可能的肌肉减少症和肌肉减少症的患病率。

结果

使用为欧洲人群推荐的截断值，EWGSOP2 中的肌肉减少症患病率较低（-6.6%；p<0.001）。与 EWGSOP 相比，EWGSOP2 中的可能肌肉减少症（即前肌肉减少症）的患病率更高（+7.8%；p<0.001）。EWGSOP 和 EWGSOP2 之间的一致性为中度（K=0.45；IC=0.40-0.51）。使用特定人群的肌肉力量和四肢肌肉质量截断值，EWGSOP2 中的可能肌肉减少症患病率较高（46.5%；p<0.001）。与 EWGSOP 相比，EWGSOP2 中的一致性为中度（K=0.48；IC=0.42-0.52）。

结论

与使用常规截断值的 EWGSOP 相比，新的 EWGSOP2 共识低估了肌肉减少症的患病率。使用 EWGSOP（低肌肉质量）的前肌肉减少症的患病率低于新的 EWGSOP2（低肌肉力量）的可能肌肉减少症。在这两种情况下，EWGSOP2 和 EWGSOP 之间的一致性为中度。原始和新共识之间的差异对初级保健机构识别预防和治疗的新旧病例具有影响。