Aomura Daiki, Yamada Yosuke, Harada Makoto, Hashimoto Koji, Kamijo Yuji
Department of Nephrology, Shinshu University School of Medicine, Matsumoto, Japan.
Front Med (Lausanne). 2021 Sep 14;8:744581. doi: 10.3389/fmed.2021.744581. eCollection 2021.
Delirium in older inpatients is a serious problem. The presence of a window in the intensive care unit has been reported to improve delirium. However, no study has investigated whether window-side bed placement is also effective for delirium prevention in a general ward. This study aims to clarify the association between admission to a window-side bed and delirium development in older patients in a general ward. This research is designed as a retrospective cohort study of older patients admitted to the internal medicine departments of Shinshu University Hospital, Japan. The inclusion criteria were the following: (1) admitted to hospital internal medicine departments between April 2009 and December 2018, (2) older than 75 years, (3) admitted to a multi-patient room in a general ward, and (4) unplanned admission. The number of eligible patients was 1,556. This study is a comparison of 495 patients assigned to a window-side bed (window group) with 1,061 patients assigned to a non-window-side bed (non-window group). When patients were transferred to the other type bed after admission, observation was censored. The main outcome of interest was "delirium with event" (e.g., the use of medication or physical restraint for delirium) within 14 days after admission as surveyed by medical chart review in a blinded manner. The patients had a median age of 80 years and 38.1% were female. The main outcome was recorded in 36 patients in the window group (10.7 per thousand person-days) and 84 in the non-window group (11.7 per thousand person-days). Log-rank testing showed no significant difference between the groups ( = 0.78). Multivariate analysis with Cox regression modeling also revealed no significant association for the window group with main outcome development (adjusted hazard ratio 0.90, 95% confidence interval of 0.61-1.34). Admission to a window-side bed did not prevent delirium development in older patients admitted to a general ward.
老年住院患者的谵妄是一个严重问题。据报道,重症监护病房设置窗户有助于改善谵妄状况。然而,尚无研究调查靠窗床位安置对普通病房谵妄预防是否也有效。本研究旨在阐明普通病房中老年患者入住靠窗床位与谵妄发生之间的关联。本研究设计为一项针对日本信州大学医院内科收治的老年患者的回顾性队列研究。纳入标准如下:(1)2009年4月至2018年12月期间入住医院内科;(2)年龄超过75岁;(3)入住普通病房的多人病房;(4)非计划入院。符合条件的患者有1556例。本研究将495例分配到靠窗床位的患者(靠窗组)与1061例分配到非靠窗床位的患者(非靠窗组)进行比较。患者入院后转至其他类型床位时,观察即终止。主要关注结局为入院后14天内“伴有事件的谵妄”(例如,因谵妄使用药物或身体约束),通过盲态方式查阅病历进行调查。患者的中位年龄为80岁,女性占38.1%。靠窗组有36例患者出现主要结局(每千人日10.7例),非靠窗组有84例(每千人日11.7例)。对数秩检验显示两组之间无显著差异(P = 0.78)。Cox回归模型的多变量分析也显示,靠窗组与主要结局发生之间无显著关联(调整后风险比为0.90,95%置信区间为0.61 - 1.34)。入住靠窗床位并不能预防普通病房中老年患者谵妄的发生。