儿童多系统炎症综合征合并小脑炎：病例报告。
Acute Cerebellitis in MIS-C: A Case Report.
机构信息
From the Department of Pediatric Intensive Care Unit, Bakirköy Dr. Sadi Konuk Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Pediatric Radiology, Bakirköy Dr. Sadi Konuk Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.
出版信息
Pediatr Infect Dis J. 2022 Jan 1;41(1):e16-e18. doi: 10.1097/INF.0000000000003358.
BACKGROUND
Coronavirus disease-2019 (COVID-19) is characterized predominantly by respiratory symptoms and has affected a small subset of children. Multisystem inflammatory syndrome in children (MIS-C) has been reported in children following COVID-19. There is increasing report that COVID-19 may also lead to neurologic manifestations. Cerebellar lesions may be observed in viral infections.
CASE REPORT
We report a child with MIS-C related to severe acute respiratory syndrome coronavirus 2, who developed cerebellar lesion during the disease course. Encephalopathy was the first central nervous system symptom. His consciousness improved but he developed clinical signs of cerebellar dysfunction including ataxia, dysarthria and nystagmus. Brain magnetic resonance imaging (MRI) revealed symmetrical pathological signal changes in both cerebellar hemispheres.
CONCLUSION
We demonstrated the first child with MIS-C to develop cerebellar lesion on brain MRI, suggestive of cerebellitis.
背景
新型冠状病毒病 2019（COVID-19）主要表现为呼吸系统症状，仅一小部分儿童受其影响。有报道称，儿童在感染 COVID-19 后会出现儿童多系统炎症综合征（MIS-C）。越来越多的报告表明，COVID-19 也可能导致神经系统表现。小脑病变可能见于病毒感染。
病例报告
我们报告了一例与严重急性呼吸综合征冠状病毒 2 相关的 MIS-C 患儿，在疾病过程中出现小脑病变。脑病是中枢神经系统的第一个症状。患儿意识改善，但出现小脑功能障碍的临床症状，包括共济失调、构音障碍和眼球震颤。脑部磁共振成像（MRI）显示双侧小脑半球对称的病理信号改变。
结论
我们首次报道了一例 MIS-C 患儿在脑部 MRI 上出现小脑病变，提示小脑炎。
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