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抗噪声介质调制双沟槽透明栅极工程MOSFET作为无标记生物传感器:方案与研究

Noise immune dielectric modulated dual trench transparent gate engineered MOSFET as a label free biosensor: proposal and investigation.

作者信息

Sen Dipanjan, De Arpan, Goswami Bijoy, Shee Sharmistha, Sarkar Subir Kumar

机构信息

Department of Electronics and Telecommunication Engineering, Jadavpur University, Kolkata, India.

出版信息

J Comput Electron. 2021;20(6):2594-2603. doi: 10.1007/s10825-021-01780-x. Epub 2021 Sep 30.

Abstract

We propose and investigate a biosensor based on a transparent dielectric-modulated dual-trench gate-engineered metal-oxide-semiconductor field-effect transistor (DM DT GE-MOSFET) for label-free detection of biomolecules with enhanced sensitivity and efficiency. Various sensing parameters such as the / ratio and the threshold voltage shift are evaluated as metrics to validate the proposed sensing device. Additionally, (the sensitivity) is also analyzed, considering both positively and negatively charged biomolecules. In addition, radiofrequency (RF) sensing parameters such as the transconductance gain and the cutoff frequency are taken into account to provide further insight into the sensitivity of the proposed device. Furthermore, the linearity, distortion, and noise immunity of the device are evaluated to confirm the overall performance of the biosensor at high (GHz) frequency. The results indicate that the proposed biosensor exhibits a value of 0.68 for positively charged biomolecules at a very low drain bias of 0.2 V. The proposed device can thus be used as an alternative to conventional FET-based biosensors.

摘要

我们提出并研究了一种基于透明介电调制双沟槽栅工程金属氧化物半导体场效应晶体管(DM DT GE-MOSFET)的生物传感器,用于无标记检测生物分子,具有更高的灵敏度和效率。评估了各种传感参数,如/比率和阈值电压偏移,作为验证所提出传感装置的指标。此外,还分析了(灵敏度),同时考虑了带正电和带负电的生物分子。此外,还考虑了射频(RF)传感参数,如跨导增益和截止频率,以进一步深入了解所提出装置的灵敏度。此外,还评估了该装置的线性度、失真和抗噪声能力,以确认生物传感器在高(GHz)频率下的整体性能。结果表明,所提出的生物传感器在0.2 V的极低漏极偏置下,对带正电生物分子的 值为0.68。因此,所提出的装置可以用作传统基于场效应晶体管的生物传感器的替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e63/8481763/684a1741a002/10825_2021_1780_Fig1_HTML.jpg

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