Infectious Diseases Department, Hôpitaux Civils de Colmar, 39, avenue de la Liberté, 68024 Colmar cedex, France.
Clinical Research Department, Hôpitaux Civils de Colmar, Colmar, France.
Infect Dis Now. 2022 Feb;52(1):35-39. doi: 10.1016/j.idnow.2021.10.002. Epub 2021 Oct 8.
Two COVID-19 epidemic waves occurred in France in 2020. This single-center retrospective study compared patients' characteristics and outcomes.
We included all patients with confirmed COVID-19 admitted to Colmar Hospital in March (n=600) and October/November (n=205) 2020.
Median ages, sex ratio, body mass index, and number of comorbidities were similar in wave 1 and 2 patients. Significant differences were found for temperature (38°C vs. 37.2), need for oxygen (38.6% vs. 26.8%), high-flow cannula (0% vs. 8.3%), and steroid use (6.3% vs. 54.1%). Intensive care unit (ICU) hospitalizations (25.5% vs. 15.1%, OR: 0.44, 95% CI [0.28; 0.68], P=0.002) and deaths (19.2% vs. 12.7%, OR: 0.61, 95% CI [0.37; 0.98], P=0.04) decreased during the second wave. Except for cardiovascular events (5.5% vs. 10.2%), no change was observed in extrapulmonary events.
Deaths and ICU hospitalizations were significantly reduced during the second epidemic wave.
2020 年，法国出现了两波 COVID-19 疫情。本单中心回顾性研究比较了患者的特征和结局。
我们纳入了 2020 年 3 月（n=600）和 10 月/11 月（n=205）在科尔马医院确诊 COVID-19 的所有患者。
第 1 波和第 2 波患者的中位年龄、性别比、体重指数和合并症数量相似。第 2 波患者的体温（38°C 比 37.2°C）、需要吸氧（38.6%比 26.8%）、高流量鼻导管（0%比 8.3%）和使用类固醇（6.3%比 54.1%）的比例存在显著差异。第 2 波患者的 ICU 住院率（25.5%比 15.1%，OR：0.44，95%CI [0.28; 0.68]，P=0.002）和死亡率（19.2%比 12.7%，OR：0.61，95%CI [0.37; 0.98]，P=0.04）有所降低。除了心血管事件（5.5%比 10.2%）外，肺外事件无变化。
第 2 波疫情期间，死亡和 ICU 住院率显著降低。
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