法国东北部 COVID-19 住院患者在第一波和第二波疫情期间基线特征和重症结局的演变。
Evolution of baseline characteristics and severe outcomes in COVID-19 inpatients during the first and second waves in Northeastern France.
机构信息
Infectious Diseases Department, Hôpitaux Civils de Colmar, 39, avenue de la Liberté, 68024 Colmar cedex, France.
Clinical Research Department, Hôpitaux Civils de Colmar, Colmar, France.
出版信息
Infect Dis Now. 2022 Feb;52(1):35-39. doi: 10.1016/j.idnow.2021.10.002. Epub 2021 Oct 8.
OBJECTIVES
Two COVID-19 epidemic waves occurred in France in 2020. This single-center retrospective study compared patients' characteristics and outcomes.
PATIENTS AND METHODS
We included all patients with confirmed COVID-19 admitted to Colmar Hospital in March (n=600) and October/November (n=205) 2020.
RESULTS
Median ages, sex ratio, body mass index, and number of comorbidities were similar in wave 1 and 2 patients. Significant differences were found for temperature (38°C vs. 37.2), need for oxygen (38.6% vs. 26.8%), high-flow cannula (0% vs. 8.3%), and steroid use (6.3% vs. 54.1%). Intensive care unit (ICU) hospitalizations (25.5% vs. 15.1%, OR: 0.44, 95% CI [0.28; 0.68], P=0.002) and deaths (19.2% vs. 12.7%, OR: 0.61, 95% CI [0.37; 0.98], P=0.04) decreased during the second wave. Except for cardiovascular events (5.5% vs. 10.2%), no change was observed in extrapulmonary events.
CONCLUSIONS
Deaths and ICU hospitalizations were significantly reduced during the second epidemic wave.
目的
2020 年，法国出现了两波 COVID-19 疫情。本单中心回顾性研究比较了患者的特征和结局。
患者和方法
我们纳入了 2020 年 3 月（n=600）和 10 月/11 月（n=205）在科尔马医院确诊 COVID-19 的所有患者。
结果
第 1 波和第 2 波患者的中位年龄、性别比、体重指数和合并症数量相似。第 2 波患者的体温（38°C 比 37.2°C）、需要吸氧（38.6%比 26.8%）、高流量鼻导管（0%比 8.3%）和使用类固醇（6.3%比 54.1%）的比例存在显著差异。第 2 波患者的 ICU 住院率（25.5%比 15.1%，OR：0.44，95%CI [0.28; 0.68]，P=0.002）和死亡率（19.2%比 12.7%，OR：0.61，95%CI [0.37; 0.98]，P=0.04）有所降低。除了心血管事件（5.5%比 10.2%）外，肺外事件无变化。
结论
第 2 波疫情期间，死亡和 ICU 住院率显著降低。
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