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1 型或 2 型糖尿病患者使用速效胰岛素的糖尿病技术使用的成本和结果比较。

Costs and Outcomes Comparison of Diabetes Technology Usage Among People With Type 1 or 2 Diabetes Using Rapid-Acting Insulin.

机构信息

Eli Lilly and Company, Indianapolis, IN, USA.

出版信息

J Diabetes Sci Technol. 2023 Mar;17(2):439-448. doi: 10.1177/19322968211052081. Epub 2021 Oct 15.

Abstract

BACKGROUND

Does initiation of a continuous glucose monitor (CGM) or insulin pump lower health care utilization and/or costs?

METHODS

Distinct cohorts of people with type 1 diabetes (T1D) or type 2 diabetes (T2D) using a blood glucose monitor (BGM), CGM, pump, or CGM with pump were identified from a large claims database. Patients ≥40 years old with 12 months of continuous enrollment before and after the device start date qualified for the study. Outcomes included one-year medical utilization and costs (minus device) for events such as hospitalizations and office visits. Generalized linear models were fitted, controlling for numerous baseline covariates. The Holm method corrected for the multiplicity of hypotheses tested.

RESULTS

Of the 8235 total patients, the BGM control group was the largest, had the lowest percentage of patients with T1D, and was significantly different from the device groups in most baseline categories. Formally, only two comparisons were statistically significant: Compared with BGM, the pump cohort had greater adjusted first-year total medical and office visit costs. Other secondary outcomes such as days hospitalized, emergency department visits and labs, favored pump. Most endpoints were favorable for CGM. Results for CGM with pump generally were intermediate between CGM and pump alone.

CONCLUSIONS

During a one-year follow-up, unadjusted medical costs of both CGM and pump appear lower than BGM, but multivariable modeling yielded adjusted savings only for CGM use. Economic benefits might be observable sooner for CGMs than for pumps. Generalized linear models fitted to health care utilization event rates produced favorable results for both CGM and pump.

摘要

背景

启动连续血糖监测仪(CGM)或胰岛素泵是否会降低医疗保健的利用和/或成本?

方法

从大型索赔数据库中确定了使用血糖仪(BGM)、CGM、泵或带泵的 CGM 的 1 型糖尿病(T1D)或 2 型糖尿病(T2D)患者的不同队列。在设备开始日期前和后有 12 个月连续入组且年龄≥40 岁的患者有资格参加研究。结果包括住院和就诊等事件的一年医疗利用和成本(减去设备)。通过广义线性模型进行拟合,并控制了大量基线协变量。Holm 法校正了测试的假设的多重性。

结果

在 8235 名总患者中,BGM 对照组最大,T1D 患者比例最低,并且在大多数基线类别中与设备组显著不同。从形式上讲,只有两个比较具有统计学意义:与 BGM 相比,泵组在第一年的总医疗和就诊费用方面有更高的调整。其他次要结果,如住院天数、急诊就诊和实验室检查,有利于泵。大多数终点对 CGM 有利。CGM 与泵联合使用的结果通常介于 CGM 和泵单独使用之间。

结论

在一年的随访期间,CGM 和泵的未经调整的医疗成本似乎低于 BGM,但多变量模型仅为 CGM 的使用产生了调整后的节省。CGM 的经济效益可能比泵更早显现。拟合医疗保健利用事件率的广义线性模型对 CGM 和泵均产生了有利的结果。

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