A Novel Approach to Boosting Glutathione via Iontophoresis.

Two cases (a 73 and a 67-year-old) with low serum reduced glutathione (GSH) were supplemented with GSH using IontoPatch™ (IontoPatch, St. Paul, USA) to determine whether GSH serum levels could be restored to within the reference range using this technology. A 1 mL dose of a 200 mg/mL saline solution of GSH was added to the patch's negative electrode for each treatment. The patch was applied on the upper arm's skin and was worn for six consecutive days for at least four hours each day. Serum levels of GSH were assessed at baseline and days 7 and 23 after treatment was initiated. In both cases, serum GSH levels increased after seven days of treatment (64.4 and 21.8%). Serum GSH levels then decreased between days 7 and 23 to 44.5 and 17.2% above baseline. There were no adverse events reported in either case. More extensive studies should be conducted to determine the pharmacokinetics, safety of long-term supplementation, and supplementation health benefits.