丙戊酸治疗 2 岁以下癫痫儿童。
Valproic acid for children below 2 years of age with epilepsy.
机构信息
From the Department of Pediatrics (Muthaffar), and from the Faculty of Pharmacy (Almahmudi, Alrabghi, Bin Mahfouz, Alfawaz), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
出版信息
Neurosciences (Riyadh). 2021 Oct;26(4):357-365. doi: 10.17712/nsj.2021.4.20210075.
OBJECTIVES
To evaluate the efficacy of valproic acid (VPA) in a cohort of children below 2 years of age. We also aim to review the characteristics of such patients and the role and safety of VPA for this age group.
METHODS
A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020.
RESULTS
The cohort for this study includes 50 children below the age of 2 years (25 males, 25 females). Aged 3 months to 23 months at commencing valproic acid. The mean age of seizure onset was 9 months and the mean age of starting valproic acid was 16 months. Thirty-two patients (64%) had more than 50% seizure improvement after valproic acid. Eleven patients (22%) were seizure-free. No statistical significance abnormalities in blood count indices and ammonia were seen during the treatment period. Two patients had dose-related lethargy that improved after decreasing their dosage. Asymptomatic mild elevation in glutamate dehydrogenase was noticed in 18% of patients.
CONCLUSION
Using valproic acid in infants and children below the age of 2 years can be considered as a safe and effective treatment option for epilepsy in this age group.
目的
评估丙戊酸（VPA）在 2 岁以下儿童队列中的疗效。我们还旨在回顾此类患者的特征以及 VPA 对该年龄组的作用和安全性。
方法
对沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院的儿童进行回顾性图表审查，这些儿童在 2016 年 1 月至 2020 年 1 月期间被诊断为癫痫并接受丙戊酸治疗，年龄在 2 岁以下。
结果
本研究的队列包括 50 名年龄在 2 岁以下的儿童（25 名男性，25 名女性）。开始服用丙戊酸时年龄为 3 个月至 23 个月。癫痫发作的平均年龄为 9 个月，开始服用丙戊酸的平均年龄为 16 个月。32 名患者（64%）在服用丙戊酸后癫痫发作改善超过 50%。11 名患者（22%）无癫痫发作。在治疗期间，血常规指数和氨无统计学意义异常。两名患者出现剂量相关的昏睡，减少剂量后改善。18%的患者出现无症状的轻度谷氨酸脱氢酶升高。
结论
在 2 岁以下婴儿和儿童中使用丙戊酸可以被认为是该年龄组癫痫的一种安全有效的治疗选择。
Zotero 插件