核酸生物传感器检测限的演进 III.
Evolution of nucleic acids biosensors detection limit III.
机构信息
Institute of Chemistry for Life and Health Sciences (iCLeHS), Synthesis, Electrochemistry, Imaging and Analytical Systems for Diagnosis (SEISAD) Team, PSL Research University, CNRS, Chimie ParisTech, 75231, Paris, France.
Faculté de Pharmacie de Paris, Faculté de Santé, Université de Paris, 4 avenue de l'Observatoire, 75006, Paris, France.
出版信息
Anal Bioanal Chem. 2022 Jan;414(2):943-968. doi: 10.1007/s00216-021-03722-9. Epub 2021 Oct 19.
This review is an update of two previous ones focusing on the limit of detection of electrochemical nucleic acid biosensors allowing direct detection of nucleic acid target (miRNA, mRNA, DNA) after hybridization event. A classification founded on the nature of the electrochemical transduction pathway is established. It provides an overall picture of the detection limit evolution of the various sensor architectures developed during the last three decades and a critical report of recent strategies.
这是对之前两篇综述的更新，重点介绍了电化学核酸生物传感器的检测限，该传感器可以在杂交事件后直接检测核酸靶标（miRNA、mRNA、DNA）。我们建立了一个基于电化学信号转导途径性质的分类，全面展示了过去三十年中各种传感器结构的检测限演变，并对最近的一些策略进行了批判性的报告。
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