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烟囱支架技术联合栓塞术治疗主动脉弓部病变破裂

Chimney Graft Technique Combined With Embolization for Treating Ruptured Aortic Arch Lesions.

作者信息

Bao Xianhao, Zhao Yuxi, Li Tao, Wu Mingwei, Zeng Zhaoxiang, Gao Minxin, Xu Ding, Feng Jiaxuan, Feng Rui

机构信息

Department of Vascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Cardiovascular Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

出版信息

Front Cardiovasc Med. 2021 Oct 4;8:711283. doi: 10.3389/fcvm.2021.711283. eCollection 2021.

Abstract

This study aimed to share the experience in applying the chimney graft technique combined with embolization for treating aortic arch rupture under emergency conditions and evaluating early-term results in these patients. This study retrospectively included patients with ruptured aortic arch lesions who received the chimney graft technique combined with embolization between March 2016 and March 2021. The primary endpoint was a technical success, deemed as successful stent graft deployment to the planned location, patency of the target branch vessel, and absence of significant type I endoleak. The secondary endpoint was clinical success defined with the size of false lumen in follow-up remaining unchanged or decreasing over time, 30-day mortality, complication, and primary patency of chimney graft. This study included 12 patients (age, 61 ± 12 years; male, 83%). Five patients (42%) received single chimney, one patient (8%) received double chimney, and six patients (50%) received triple chimney. Intraoperative type I endoleak occurred in six patients (50%) who underwent endovascular embolization in the primary operation. Post-operative type I endoleak, evaluated by computed tomography angiography examination following the primary operation, occurred in seven patients (58%), including one patient who received endovascular embolization two times. All patients with post-operative type I endoleak were successfully re-treated using coil and Onyx glue within 1 week, and the median length of stay was 22 ± 11 days (range: 7-44 days). Overall technical success was 100%. Eleven patients had completed their follow-up (median, 12 months, range: 1-34 months), and one patient was out of contact. The 30-day mortality was 9% (1/11, post-operative death of a patient with cerebral hemorrhage). No major complications and no chimney compression, migration, occlusion, or stenosis were recorded during follow-up. Seven patients (58%) have ≥6 months of clinical follow-up time with appropriate imaging. In four (57%) of these patients, diameter stabilization was detected, whereas three (43%) experienced significant reduction (≥5 mm). The patients in this study had satisfactory early-term outcomes. The chimney graft technique combined with coil and Onyx glue embolization may be a safe and effective treatment for ruptured aortic arch lesions under emergency conditions.

摘要

本研究旨在分享在紧急情况下应用烟囱式移植物技术联合栓塞治疗主动脉弓破裂的经验,并评估这些患者的早期结果。本研究回顾性纳入了2016年3月至2021年3月期间接受烟囱式移植物技术联合栓塞治疗的主动脉弓破裂病变患者。主要终点为技术成功,定义为支架型人工血管成功置入计划位置、靶分支血管通畅且无显著I型内漏。次要终点为临床成功,定义为随访中假腔大小保持不变或随时间减小、30天死亡率、并发症以及烟囱式移植物的原发性通畅情况。本研究共纳入12例患者(年龄61±12岁;男性占83%)。5例患者(42%)接受单烟囱式移植物,1例患者(8%)接受双烟囱式移植物,6例患者(50%)接受三烟囱式移植物。在初次手术中接受血管内栓塞的6例患者(50%)发生术中I型内漏。初次手术后通过计算机断层扫描血管造影检查评估,7例患者(58%)发生术后I型内漏,其中1例患者接受了2次血管内栓塞。所有术后发生I型内漏的患者均在1周内使用弹簧圈和Onyx胶成功进行了再次治疗,中位住院时间为22±11天(范围:7 - 44天)。总体技术成功率为100%。11例患者完成了随访(中位随访时间12个月,范围:1 - 34个月),1例患者失访。30天死亡率为9%(1/11,1例脑出血患者术后死亡)。随访期间未记录到重大并发症,也未出现烟囱式移植物受压、移位、闭塞或狭窄。7例患者(58%)有≥6个月的临床随访时间及合适的影像学检查。其中4例患者(57%)检测到直径稳定,而3例患者(43%)出现显著缩小(≥5 mm)。本研究中的患者早期结果令人满意。烟囱式移植物技术联合弹簧圈和Onyx胶栓塞可能是紧急情况下治疗主动脉弓破裂病变的一种安全有效的方法。

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