抗癌药物所致心脏毒性：见解与药物遗传学
Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics.
作者信息
Adhikari Archana, Asdaq Syed Mohammed Basheeruddin, Al Hawaj Maitham A, Chakraborty Manodeep, Thapa Gayatri, Bhuyan Nihar Ranjan, Imran Mohd, Alshammari Mohammed Kanan, Alshehri Mohammed M, Harshan Aishah Ali, Alanazi Abeer, Alhazmi Bushra Dhuhayyan, Sreeharsha Nagaraja
机构信息
Pharmacology Department, Himalayan Pharmacy Institute Majhitar, Rangpo 737136, Sikkim, India.
Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia.
出版信息
Pharmaceuticals (Basel). 2021 Sep 25;14(10):970. doi: 10.3390/ph14100970.
The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. This article addresses the prevalence of cardiotoxicity mediated by commonly used chemotherapeutic and immunotherapeutic agents. The role of susceptible genes and radiation therapy in the occurrence of cardiotoxicity is also reviewed. This review also emphasizes the protective role of antioxidants and future perspectives in anticancer drug-induced cardiotoxicities.
治疗方法的进步显著提高了癌症患者的康复率。然而，这种生存率的提高也伴随着心血管表现风险的增加，包括高血压、心律失常和心力衰竭。化疗引起的心脏毒性是一种危及生命的后果，限制了几种化疗药物在临床实践中的使用。本文探讨了常用化疗药物和免疫治疗药物介导的心脏毒性的发生率。还综述了易感基因和放射治疗在心脏毒性发生中的作用。本综述还强调了抗氧化剂的保护作用以及抗癌药物诱导心脏毒性的未来研究方向。
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