一株放线菌来源的具有抗分枝杆菌活性的次生代谢产物:.

Secondary Metabolites with Antimycobacterial Activities from One Actinobacteria: .

机构信息

Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan.

Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

出版信息

Molecules. 2021 Oct 15;26(20):6236. doi: 10.3390/molecules26206236.

DOI:10.3390/molecules26206236

PMID:34684816

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8570327/

Abstract

The cultivation of one actinobacteria strain, Herbidospora yilanensis, was isolated from sediment samples collected from Yilan County City in Taiwan, resulting in the isolation of five previously undescribed compounds: herbidosporayilanensins A-E (-), and four compounds isolated from nature for the first time: herbidosporayilanensins F-I (-). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments with those of known analogues, and on the basis of HR-EI-MS mass spectrometry, their antimycobacterial activities were also evaluated.

摘要

从台湾宜兰县采集的沉积物样本中分离出一株放线菌菌株 Herbidospora yilanensis，从中分离出五种以前未描述的化合物：herbidosporayilanensins A-E（-），以及四种首次从自然界中分离出的化合物：herbidosporayilanensins F-I（-）。通过光谱分析，包括与已知类似物的 1D 和 2D-NMR 实验，以及基于高分辨率 EI-MS 质谱，阐明了它们的结构，并评估了它们的抗分枝杆菌活性。