血浆谷胱甘肽与帕金森病前驱期发病概率
Plasma Glutathione and Prodromal Parkinson's Disease Probability.
作者信息
Charisis Sokratis, Ntanasi Eva, Stamelou Maria, Xiromerisiou Georgia, Maraki Maria, Veskoukis Aristidis S, Yannakoulia Mary, Kosmidis Mary H, Anastasiou Costas A, Giagkou Nikolaos, Dardiotis Efthimios, Hadjigeorgiou Georgios, Sakka Paraskevi, Kouretas Demetrios, Stefanis Leonidas, Scarmeas Nikolaos
机构信息
1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
出版信息
Mov Disord. 2022 Jan;37(1):200-205. doi: 10.1002/mds.28826. Epub 2021 Oct 25.
BACKGROUND
A decrease in glutathione (GSH) levels is considered one of the earliest biochemical changes in Parkinson's disease (PD).
OBJECTIVE
The authors explored the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD (pPD) by examining its longitudinal associations with pPD probability trajectories.
METHODS
A total of 405 community-dwelling participants (median age [interquartile range] = 73.2 [7.41] years) without clinical features of parkinsonism were followed for a mean (standard deviation) of 3.0 (0.9) years.
RESULTS
A 1 μmol/L increase in plasma GSH was associated with 0.4% (95% confidence interval [CI], 0.1%-0.7%; P = 0.017) less increase in pPD probability for 1 year of follow-up. Compared with participants in the lowest GSH tertile, participants in the highest GSH tertile had a 12.9% (95% CI, 22.4%-2.2%; P = 0.020) slower rate of increase of pPD probability for 1 year of follow-up.
CONCLUSION
Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. © 2021 International Parkinson and Movement Disorder Society.
背景
谷胱甘肽（GSH）水平降低被认为是帕金森病（PD）最早出现的生化变化之一。
目的
作者通过研究血浆GSH与前驱性PD（pPD）概率轨迹的纵向关联，探讨血浆GSH作为pPD风险/易感性生物标志物的潜在作用。
方法
对405名无帕金森综合征临床特征的社区居住参与者（年龄中位数[四分位间距]=73.2[7.41]岁）进行了平均（标准差）3.0（0.9）年的随访。
结果
血浆GSH每增加1μmol/L，随访1年时pPD概率的增加减少0.4%（95%置信区间[CI]，0.1%-0.7%；P=0.017）。与GSH三分位数最低的参与者相比，GSH三分位数最高的参与者随访1年时pPD概率的增加速率慢12.9%（95%CI，22.4%-2.2%；P=0.020）。
结论
血浆GSH与pPD概率轨迹相关；因此，它可能有助于识别那些可能更快达到pPD诊断阈值的个体。©2021国际帕金森和运动障碍协会。
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