İnce Başak, Max Sebastian M, Plewnia Christian, Leehr Elisabeth J, Zipfel Stephan, Giel Katrin Elisabeth, Schag Kathrin
Department of Psychology, Haliç University, Istanbul, Turkey.
Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Front Psychol. 2021 Oct 12;12:721672. doi: 10.3389/fpsyg.2021.721672. eCollection 2021.
Behavioural studies demonstrate alterations in cognitive functioning, particularly impaired response inhibition and increased attentional bias towards food in binge eating disorder (BED). This pilot study aimed to investigate the neurophysiological processing of a food-specific inhibition training combined with anodal transcranial direct current stimulation (tDCS) of the right dorsolateral prefrontal cortex (DLPFC) in 16 patients with BED (mean age = 38.6, mean BMI = 33.7 kg/m). Patients performed a food-specific antisaccade task at baseline (T0) and in a cross-over design with verum vs. sham stimulation at T1 and T2. We investigated (i) event-related potentials (ERPs; N2, ERN and P3 amplitudes) while executing the task at baseline, (ii) whether baseline ERPs would predict task performance at T1 and T2 and (iii) associations between ERPs, eating disorder pathology and impulsivity at baseline. The mean amplitude of N2 was less pronounced in erroneous saccades (ES) than correct saccades (CS), whereas ERN and P3 mean amplitudes were more pronounced in ES. Moreover, the P3 mean amplitude of ES predicted the percentage of ES at both follow up-measurements irrespective of the applied stimulation (sham vs. verum). N2 in trials with correct saccades were negatively correlated with nonplanning trait impulsivity, while P3 in erroneous antisaccade trials was negatively correlated with food-related impulsivity. Overall, the findings of reduced ERN, enhanced P3 and N2 amplitude might be interpreted as difficulties in response inhibition towards food in individuals with BED. In particular, P3 predicts task outcome at follow-up and might represent a potential marker for inhibitory control processes.
行为学研究表明，暴食症（BED）患者的认知功能存在改变，尤其是反应抑制受损以及对食物的注意力偏向增加。这项初步研究旨在调查16名BED患者（平均年龄 = 38.6岁，平均BMI = 33.7kg/m²）在进行食物特异性抑制训练并结合右侧背外侧前额叶皮质（DLPFC）的阳极经颅直流电刺激（tDCS）时的神经生理过程。患者在基线期（T0）以及采用真刺激与假刺激交叉设计的T1和T2期执行食物特异性反扫视任务。我们研究了：（i）在基线期执行任务时的事件相关电位（ERP；N2、ERN和P3波幅）；（ii）基线期ERP是否能预测T1和T2期的任务表现；以及（iii）基线期ERP、饮食失调病理学和冲动性之间的关联。错误扫视（ES）时N2的平均波幅比正确扫视（CS）时不那么明显，而ES时ERN和P3的平均波幅更明显。此外，无论应用何种刺激（假刺激与真刺激），ES的P3平均波幅都能预测两次随访测量时ES的百分比。正确扫视试验中的N2与非计划性特质冲动性呈负相关，而错误反扫视试验中的P3与食物相关冲动性呈负相关。总体而言，ERN降低、P3增强以及N2波幅变化的研究结果可能被解释为BED患者在对食物的反应抑制方面存在困难。特别是，P3能预测随访时的任务结果，可能代表抑制控制过程的一个潜在标志物。
