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基于半单片 LYSO 晶体的 PET 探测器模块的定时评估。

Timing evaluation of a PET detector block based on semi-monolithic LYSO crystals.

机构信息

Instituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC-Universitat Politècnica de València, Valencia, 46022, Spain.

出版信息

Med Phys. 2021 Dec;48(12):8010-8023. doi: 10.1002/mp.15318. Epub 2021 Nov 22.

Abstract

PURPOSE

Detectors for positron emission tomography (PET) typically use two types of scintillation crystals, pixelated or monolithic. A variant of these types of scintillators are the so-called semi-monolithic crystals. They consist of a monolithic crystal segmented in one direction in pieces called slabs. These scintillators have the potential to successfully combine the benefits of pixelated and monolithic configurations, providing good timing and spatial resolutions as well as the capacity to decode the depth of interaction (DOI) information. In this work, the timing performance of a detector based on semi-monolithic crystals was studied in depth. The energy response was also evaluated.

METHODS

The semi-monolithic detector consists of 1 × 24 LYSO slabs of 25.4 × 12 × 0.95 mm each. The bottom surface of the slabs is coupled to an array of 8 × 8 silicon photomultipliers (SiPMs) of 3 × 3 mm active area, 50 μm cell size and 3.2 mm pitch. The 64 output signals were independently readout by the TOFPET2 ASIC. In order to achieve the best coincidence time resolution (CTR), four different time walk corrections were tested. Additional work investigated the best method of combining the timestamps belonging to the same event.

RESULTS

The resolvability of the slabs in the measured flood maps improves with the thickness of a light guide placed in between the scintillators and photosensors. The energy resolution does not change significantly with values as good as 13.7%. Regarding the CTR, values of 335.8, 363, 369.8, and 402.5 ps have been obtained for the whole detector for no light guide, 0.5, 1.0, and 1.5 mm thickness light guide cases, respectively. These values further improve to 276.1, 302.6, 305.6 and 336.2 ps, respectively, when energy-weighted averaging of timestamps is applied.

CONCLUSIONS

We have shown both an excellent timing resolution and good energy resolution for a PET detector based on semi-monolithic crystals. The use of light guides of different thicknesses does not significantly affect the energy resolution of the whole detector, but the timing capabilities slightly worsen with the increasing thickness of the light guide.

摘要

目的

正电子发射断层扫描(PET)探测器通常使用两种类型的闪烁晶体,即像素化或整体式。这些类型的闪烁体的一种变体是所谓的半整体式晶体。它们由在一个方向上分段的整体式晶体组成,称为薄片。这些闪烁体有可能成功地结合像素化和整体式配置的优点,提供良好的时间和空间分辨率以及探测深度交互(DOI)信息的能力。在这项工作中,深入研究了基于半整体式晶体的探测器的定时性能。还评估了能量响应。

方法

半整体式探测器由 1×24 个 LYSO 薄片组成,每个薄片的尺寸为 25.4×12×0.95mm。薄片的下表面与一个由 8×8 个硅光电倍增管(SiPM)组成的阵列耦合,每个 SiPM 的有效面积为 3×3mm,单元尺寸为 50μm,间距为 3.2mm。64 个输出信号由 TOFPET2 ASIC 独立读取。为了获得最佳的符合时间分辨率(CTR),测试了四种不同的时间漫步校正方法。此外,还研究了组合同一事件的时间戳的最佳方法。

结果

在测量的洪水图中,随着放置在闪烁体和光电传感器之间的光导的厚度增加,薄片的可分辨性得到改善。能量分辨率没有明显变化,值高达 13.7%。关于 CTR,对于整个探测器,在没有光导、0.5、1.0 和 1.5mm 厚度光导的情况下,分别获得了 335.8、363、369.8 和 402.5ps 的值。当应用时间戳的能量加权平均时,这些值进一步提高到 276.1、302.6、305.6 和 336.2ps。

结论

我们展示了基于半整体式晶体的 PET 探测器具有出色的定时分辨率和良好的能量分辨率。使用不同厚度的光导不会显著影响整个探测器的能量分辨率,但随着光导厚度的增加,定时性能会略有恶化。

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