人类细胞色素P-450（异喹胍/鹰爪豆碱型）在22号染色体上的染色体定位。
Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.
作者信息
Eichelbaum M, Baur M P, Dengler H J, Osikowska-Evers B O, Tieves G, Zekorn C, Rittner C
出版信息
Br J Clin Pharmacol. 1987 Apr;23(4):455-8. doi: 10.1111/j.1365-2125.1987.tb03075.x.
Abstract
In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.
摘要
为了确定控制人细胞色素P - 450（异喹胍/鹰爪豆碱型）的基因位于哪条染色体上，开展了多态性鹰爪豆碱氧化（PSO）与各种多态性标记的连锁研究。获得了PSO与P1血型之间连锁的阳性信息，男性和女性重组率估计值θm = θf = 0.0时，最大LOD值为LOD = 3.35。P1血型最近已被定位到22号染色体长臂上。因此可以得出结论，控制人细胞色素P - 450（异喹胍/鹰爪豆碱）的基因位于22号染色体长臂上，与P1紧密相邻。
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