Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2022;1376:45-59. doi: 10.1007/5584_2021_674.
For a very long time, viral infections have been considered as one of the most important causes of death and disability around the world. Through the viral infection, viruses as small pathogens enter the host cells and use hosts' biosynthesis machinery to replicate and collect infectious lineages. Moreover, they can modify hosts' metabolic pathways in order to their own purposes. Nowadays (in 2019-2020), the most famous type of viral infection which was caused by a novel type of coronavirus is called COVID-19 disease. It has claimed the lives of many people around the world and is a very serious threat to health. Since investigations of the effects of viruses on host metabolism using metabolomics tools may have given focuses on novel appropriate treatments, in the current review the authors highlighted the virus-host metabolic interactions and metabolomics perspective in COVID-19.
在很长一段时间里,病毒感染被认为是世界范围内导致死亡和残疾的最重要原因之一。通过病毒感染,这些微小的病原体进入宿主细胞,并利用宿主的生物合成机制进行复制和收集具有感染性的后代。此外,它们还可以改变宿主的代谢途径,以达到自身的目的。如今(2019-2020 年),由新型冠状病毒引起的最著名的病毒感染类型被称为 COVID-19 疾病。它已经夺走了世界上许多人的生命,对健康构成了非常严重的威胁。由于使用代谢组学工具研究病毒对宿主代谢的影响可能会为新型适当治疗方法提供重点,因此在当前综述中,作者强调了 COVID-19 中的病毒-宿主代谢相互作用和代谢组学观点。