Sucrose solution concentration and the intermittent access induced consumption increase.

Animals fed ad libitum consume less of a preferred additional food with daily access than with access only once every few days. With 4% sucrose solution, rats can drink over twice as much in a day if they receive it every fourth day compared to daily access. These differences are maintained when all rats are put on the same schedule. We explored the intermittency effect with 1, 4, 8, and 16% sucrose solutions available for 23 h daily or every third day in adult male rats. The consumption difference was only evident with the 4% solution. In a second experiment with a 16% solution, only a small difference was seen in the first phase. When the sucrose concentration was lowered to 4% in a second phase with alternate day access, the rats with prior every third-day access showed an immediate, pronounced elevation in consumption compared to rats with initial daily access. These results suggest that intermittency induces a long-lasting elevation in the sucrose solution's value for rats, but it may only be evident under the appropriate testing conditions. The relevance of this increased consumption for understanding human obesity and binge eating is discussed.