骨细胞与吸收耦联到骨形成的新见解。
Novel insights into the coupling of osteoclasts and resorption to bone formation.
机构信息
Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Cell and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA; Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
出版信息
Semin Cell Dev Biol. 2022 Mar;123:4-13. doi: 10.1016/j.semcdb.2021.10.008. Epub 2021 Oct 30.
Abstract
Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts (OBs). Precise coordination of these activities is required for the resorbed bone to be replaced with an equal amount of new bone in order to maintain skeletal mass throughout the lifespan. This coordination of remodeling processes is referred to as the "coupling" of resorption to bone formation. In this review, we discuss the essential role for OCs in coupling resorption to bone formation, mechanisms for this coupling, and how coupling becomes less efficient or disrupted in conditions of bone loss. Lastly, we provide perspectives on targeting coupling to treat human bone disease.
摘要
骨重建包括破骨细胞（OCs）的吸收和成骨细胞（OBs）的形成。为了在整个生命周期中维持骨量，需要精确协调这些活动，以便用等量的新骨替代被吸收的骨。这种重建过程的协调被称为“吸收与骨形成的偶联”。在这篇综述中，我们讨论了 OCs 在偶联吸收和骨形成中的重要作用、偶联的机制，以及在骨丢失的情况下偶联如何变得效率降低或失调。最后，我们提供了针对偶联以治疗人类骨骼疾病的观点。
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