reduces chemotherapy-induced nausea and vomiting: A randomized double-blind placebo-controlled clinical trial.

BACKGROUND

Chemotherapy-induced nausea and vomiting (CINV) is considered as the most common complications of chemotherapy which has a detrimental influence on the quality of life of patients with cancer. We assessed the efficacy of Apple () syrup for reducing CINV.

MATERIALS AND METHODS

This study was a randomized, double-blind, placebo-controlled trial carried out in a Hematooncology Clinic affiliated to Mazandaran University of Medical Sciences, Sari, Iran (from October 2017 to August 2018). Subjects were randomly allocated to receive apple syrup or placebo along with their previous antiemetic treatment and chemotherapy regimen, three times a day. Thirty-four patients received apple syrup ( = 16) or placebo ( = 18). Statistical analysis was conducted using SPSS software Version 21 (SPSS Inc., Chicago, IL, USA). A < 0.05 indicated statistical significance.

RESULTS

Both acute and delayed nausea grades were significantly lower in syrup in comparison to placebo syrup ( = 0.001 and 0.001, respectively). The duration of nausea ( = 0.04) was lower in intervention group compared to placebo group.

CONCLUSION

These findings demonstrated that syrup can reduce the severity and duration of nausea in cancer patients who received chemotherapy.