性别和年龄特异性 ACE2 调节：深入了解重症 COVID-19 的易感性。
Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility.
机构信息
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
出版信息
J Mol Cell Cardiol. 2022 Mar;164:13-16. doi: 10.1016/j.yjmcc.2021.11.003. Epub 2021 Nov 11.
Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load dictates disease severity, we investigated the expression, protein levels, and activity of ACE2 and TMPRSS2. Our data reveal that aged males have elevated ACE2 in both mice and humans across organs. We report the first comparative study comprehensively investigating the impact of sex and age in murine and human levels of ACE2 and TMPRSS2, to begin to elucidate the sex bias in COVID-19 severity.
与女性相比，老年男性在 COVID-19 严重程度、住院和死亡率方面的比例更高。血管紧张素转换酶 2（ACE2）和跨膜丝氨酸蛋白酶 2（TMPRSS2）有助于 SARS-CoV-2 病毒进入，并且可能具有性别二态性调节。由于病毒载量决定疾病严重程度，我们研究了 ACE2 和 TMPRSS2 的表达、蛋白水平和活性。我们的数据表明，老年男性在小鼠和人类的多个器官中 ACE2 水平升高。我们报告了第一个比较研究，全面调查了 ACE2 和 TMPRSS2 在小鼠和人类水平上的性别和年龄的影响，以开始阐明 COVID-19 严重程度的性别偏见。
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