Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA.
Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA.
Vet Clin North Am Equine Pract. 2021 Dec;37(3):639-656. doi: 10.1016/j.cveq.2021.08.003.
Sepsis or systemic inflammatory response syndrome (SIRS) -associated laminitis is a sequela to primary inflammatory conditions (eg, colitis, ischemic intestinal injury, pneumonia, metritis) and results from a dysregulated systemic inflammatory response that ultimately affects the digital lamellae. Local chemokine production, leukocyte migration, and proinflammatory mediator production occur within the lamellae that can lead to catastrophic lamellar failure. Controlling the primary disease, providing supportive care and anti-inflammatory therapy, applying digital cryotherapy, and providing mechanical support are cornerstones to the prevention of sepsis/SIRS-associated laminitis. Novel therapies targeting specific signaling pathways may provide additional therapeutic options in the future.
脓毒症或全身炎症反应综合征（SIRS）相关的蹄叶炎是原发性炎症性疾病（如结肠炎、缺血性肠损伤、肺炎、子宫炎）的后遗症，源于失调的全身炎症反应，最终影响到指（趾）间的蹄真皮。局部趋化因子的产生、白细胞的迁移和促炎介质的产生发生在蹄真皮中，这可能导致灾难性的蹄真皮坏死。控制原发性疾病、提供支持性护理和抗炎治疗、应用趾部冷冻疗法以及提供机械支持是预防脓毒症/SIRS 相关蹄叶炎的基石。针对特定信号通路的新型疗法可能为未来提供更多的治疗选择。
Zotero 插件