顺铂对大鼠睾丸的毒性作用：番茄红素和N-乙酰半胱氨酸的改善作用
Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine.
作者信息
Elsayed Asmaa, Elkomy Ashraf, Alkafafy Mohamed, Elkammar Reda, El-Shafey Anwar, Soliman Ahmed, Aboubakr Mohamed
机构信息
Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qalyubiyya, 13736, Egypt.
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
出版信息
Environ Sci Pollut Res Int. 2022 Apr;29(16):24077-24084. doi: 10.1007/s11356-021-17736-4. Epub 2021 Nov 25.
Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular toxicity mediated by cisplatin (CP) in rats. Forty-nine rats were divided into 7 groups (n = 7); these groups included the control group (saline, PO), LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP (7.5 mg/kg, IP) on the 27th day of the study, LP + CP, NAC+CP, and LP + NAC + CP. Serum levels of testosterone were decreased following CP injection. Malondialdehyde (MDA) has been increased with considerable glutathione (GSH), and dismutase superoxide (SOD) and catalase (CAT) decline in the testis tissues after CP injection. CP caused severe alterations in testicular tissues and elevated caspase-3 expression. Besides that, LP and/or NAC administration improved CP-induced testicular toxicity and apoptosis, probably via their antioxidant properties.
评估了番茄红素（LP）和N-乙酰半胱氨酸（NAC）对顺铂（CP）介导的大鼠睾丸毒性的保护作用。49只大鼠分为7组（n = 7）；这些组包括对照组（生理盐水，口服）、LP组（10 mg/kg，口服）、NAC组（150 mg/kg，口服）、在研究第27天给予CP组（7.5 mg/kg，腹腔注射）、LP + CP组、NAC + CP组和LP + NAC + CP组。注射CP后血清睾酮水平降低。注射CP后，睾丸组织中的丙二醛（MDA）增加，同时谷胱甘肽（GSH）显著减少，超氧化物歧化酶（SOD）和过氧化氢酶（CAT）下降。CP导致睾丸组织发生严重改变并使半胱天冬酶-3表达升高。除此之外，给予LP和/或NAC可改善CP诱导的睾丸毒性和细胞凋亡，这可能是通过它们的抗氧化特性实现的。
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