College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Nutrients. 2021 Oct 26;13(11):3801. doi: 10.3390/nu13113801.
Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility of using natural products for pancreatic cancer is increasing. In this study, 68 natural products that have anti-pancreatic cancer effects reported within five years were reviewed. The mechanisms of anti-cancer effects were divided into four types: apoptosis, anti-metastasis, anti-angiogenesis, and anti-resistance. Most of the studies were conducted for natural products that induce apoptosis in pancreatic cancer. Among them, plant extracts such as account for the major portion. Some natural products, including , Coix seed, etc., showed multi-functional properties. Natural products could be beneficial candidates for treating pancreatic cancer.
胰腺癌是全球第七大致命癌症，由于预后不良和治疗困难，被认为是一种复杂的癌症。尽管采用了包括手术治疗和化疗在内的所有常规治疗方法，但其死亡率仍然很高。因此，使用天然产物治疗胰腺癌的可能性正在增加。在这项研究中，我们回顾了近五年来报道的 68 种具有抗胰腺癌作用的天然产物。抗癌作用的机制分为四类：细胞凋亡、抗转移、抗血管生成和抗耐药性。大多数研究都是针对能诱导胰腺癌细胞凋亡的天然产物进行的。其中，植物提取物如 占了主要部分。一些天然产物，如 、薏苡仁等，表现出多功能特性。天然产物可能是治疗胰腺癌的有益候选药物。
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