血清癌胚抗原相关细胞黏附分子 1 水平与肝细胞癌。
Serum Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Patients with Hepatocellular Carcinoma.
机构信息
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Division of Immunology, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
出版信息
Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3521-3524. doi: 10.31557/APJCP.2021.22.11.3521.
OBJECTIVE
To evaluate the clinical value of carcinoembryonic-antigen-related cell-adhesion molecule 1 (CEACAM1) in predicting the severity of hepatocellular carcinoma(HCC).
METHODS
We evaluated 40 healthy subjects and 40 HCC patients by collecting venous blood for the comparison. Serum CEACAM1 was detected using the Human CEACAM1 ELISA Kit. Other laboratory chemistries were analyzed by standard methods.
RESULTS
The serum level of CEACAM1 was not different between HCC patients and healthy subjects (p=0.0069). There was a correlation between serum CEACAM1 level and total bilirubin, and direct bilirubin. There was also a statistically significant difference among serum CEACAM1 levels stratified by BCLC staging and MELD score at the cut-point of 18. Lower platelet count, higher levels of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were observed in HCC patients.
CONCLUSION
An increase of serum CEACAM1 level was associated with cholestasis. The role of this molecule in HCC diagnosis was unclear. However, serum CAECAM1 may be useful to predict the severity in HCC patients.
目的
评估癌胚抗原相关细胞黏附分子 1（CEACAM1）在预测肝细胞癌（HCC）严重程度中的临床价值。
方法
通过采集静脉血，我们对 40 名健康受试者和 40 名 HCC 患者进行了评估。采用人 CEACAM1 ELISA 试剂盒检测血清 CEACAM1。其他实验室化学物质采用标准方法进行分析。
结果
HCC 患者和健康受试者的血清 CEACAM1 水平无差异（p=0.0069）。血清 CEACAM1 水平与总胆红素和直接胆红素之间存在相关性。在 BCLC 分期和 MELD 评分的切点为 18 时，CEACAM1 血清水平分层之间存在统计学差异。HCC 患者的血小板计数较低，天门冬氨酸氨基转移酶、丙氨酸氨基转移酶和碱性磷酸酶水平较高。
结论
血清 CEACAM1 水平的升高与胆汁淤积有关。该分子在 HCC 诊断中的作用尚不清楚。然而，血清 CAECAM1 可能有助于预测 HCC 患者的严重程度。
Zotero 插件