Sherrill Andrew M, Patton Samantha C, Bliwise Donald L, Yasinski Carly W, Maples-Keller Jessica, Rothbaum Barbara O, Rauch Sheila A M
Department of Psychiatry and Behavioral Sciences.
Psychol Trauma. 2022 Feb;14(2):173-177. doi: 10.1037/tra0001098. Epub 2021 Nov 29.
The impact of disrupted sleep on the effectiveness of prolonged exposure (PE) therapy for posttraumatic stress disorder (PTSD) is not well understood. Researchers have suggested that comorbid sleep disorders contribute to nonresponse by impairing therapeutic mechanisms such as emotional processing of trauma memories and extinction in cued fear conditioning. Several studies indicate daytime sleepiness, insomnia, and nightmares are correlated with PTSD symptom severity. However, a recent randomized controlled trial found that these sleep disorder symptoms did not affect PTSD symptom change over the course of massed PE (i.e., daily sessions across 2 weeks).
The current study used an ecologically valid clinical sample to examine whether daytime sleepiness, insomnia, and nightmares interfere with the slope of symptom change in massed PE.
Results indicate that all 3 sleep disorder symptoms correlate with PTSD symptom severity on the first day of treatment but were not associated with symptom change.
These findings are consistent with the expectation that the daily structure of massed PE may enhance treatment engagement in patients who are typically drowsy or not well-rested, thus facilitating fear extinction. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
睡眠中断对创伤后应激障碍(PTSD)延长暴露(PE)治疗效果的影响尚不清楚。研究人员认为,共病的睡眠障碍通过损害诸如创伤记忆的情绪加工和线索恐惧条件反射中的消退等治疗机制,导致治疗无反应。几项研究表明,白天嗜睡、失眠和噩梦与PTSD症状严重程度相关。然而,最近一项随机对照试验发现,这些睡眠障碍症状在密集PE治疗过程中(即两周内每天治疗)并不影响PTSD症状的变化。
本研究使用生态效度高的临床样本,以检验白天嗜睡、失眠和噩梦是否会干扰密集PE治疗中症状变化的斜率。
结果表明,所有三种睡眠障碍症状在治疗第一天都与PTSD症状严重程度相关,但与症状变化无关。
这些发现符合预期,即密集PE的每日治疗结构可能会提高通常困倦或休息不好的患者的治疗参与度,从而促进恐惧消退。(PsycInfo数据库记录(c)2022美国心理学会,保留所有权利)