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静脉注射脂质乳剂疗法成功治疗一名维拉帕米中毒儿童。

A successful treatment with intravenous lipid emulsion therapy in a child with verapamil poisoning.

作者信息

Havan Merve, Kendirli Tanıl, Özcan Serhan, Doğan Melih Timuçin, Yiğit Ahmet Onur, Uçar Tayfun

机构信息

Department of Pediatric Intensive Care, School of Medicine, Ankara University, Ankara, Turkey.

Department of Pediatric Cardiology, School of Medicine, Ankara University, Ankara, Turkey.

出版信息

Turk J Emerg Med. 2021 Oct 29;21(4):217-220. doi: 10.4103/2452-2473.329626. eCollection 2021 Oct-Dec.

Abstract

In recent years, intravenous lipid emulsion therapy (ILE) was used for lipophilic drug intoxications, and successful results were obtained. In the literature, there is a small number of reported cases about verapamil intoxication and ILE therapy in the pediatric age group. We used ILE therapy in a 14-year-old girl with verapamil intoxication in the 2 h of the pediatric intensive care unit stay, before using traditional treatments such as glucagon and hyperinsulinemic euglycemia. She had resistant bradycardia and hypotension which was unresponsive to inotropic agents and a successful result was obtained after using ILE treatment. We believe our report may contribute to the early use of ILE therapy for toxicity with calcium channel blockers such as verapamil in pediatric patients.

摘要

近年来,静脉脂质乳剂疗法(ILE)被用于亲脂性药物中毒,并取得了成功。在文献中,关于儿科年龄组维拉帕米中毒及ILE治疗的报道病例较少。我们在一名14岁维拉帕米中毒女孩入住儿科重症监护病房2小时内,在使用胰高血糖素和高胰岛素正常血糖等传统治疗方法之前,就采用了ILE治疗。她出现顽固性心动过缓和低血压,对强心剂无反应,使用ILE治疗后取得了成功。我们相信我们的报告可能有助于儿科患者早期使用ILE治疗维拉帕米等钙通道阻滞剂中毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/8593422/924f4d7c2986/TJEM-21-217-g001.jpg

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