钙拮抗剂（PY 108 - 068）治疗可能会进一步降低急性中风缺血区域的血流量。

Calcium antagonist (PY 108-068) treatment may further decrease flow in ischemic areas in acute stroke.

作者信息

Vorstrup S, Andersen A, Blegvad N, Paulson O B

出版信息

J Cereb Blood Flow Metab. 1986 Apr;6(2):222-9. doi: 10.1038/jcbfm.1986.35.

DOI:10.1038/jcbfm.1986.35

Abstract

The effect of the possible influence of a new calcium antagonist, PY 108-068, on regional CBF was studied in patients suffering acute ischemic stroke. The dosage was 1.5 + 2.5 mg intravenously in six patients (series 1) and 2.5 + 5.0 mg intravenously in five other patients (series 2). CBF was measured before and after treatment by xenon-133 inhalation and single-photon emission computed tomography (Tomomatic 64). In the first series, no changes in hemispheric CBF, MABP, or clinical symptoms were noted after treatment, but one patient showed an increase of CBF in part of the periinfarct area. In the second series, slight increases in mean hemispheric flow values were seen, but in three of the five patients CBF decreased even further in the ischemic area. MABP decreased by 13%, and the clinical symptoms were unchanged.

摘要

在急性缺血性中风患者中研究了一种新型钙拮抗剂PY 108 - 068对局部脑血流量（CBF）可能产生的影响。6例患者（第1组）静脉注射剂量为1.5 + 2.5毫克，另外5例患者（第2组）静脉注射剂量为2.5 + 5.0毫克。治疗前后通过吸入氙-133和单光子发射计算机断层扫描（Tomomatic 64）测量CBF。在第1组中，治疗后半球CBF、平均动脉血压（MABP）或临床症状均无变化，但1例患者梗死周边部分区域的CBF有所增加。在第2组中，半球平均血流值略有增加，但5例患者中有3例缺血区域的CBF进一步下降。MABP下降了13%，临床症状未改变。