使用 Mediclore® 和他汀类药物预防腹腔内粘连。

Prevention of Intra-Abdominal Adhesions Using the Combination of Mediclore® and a Statin.

机构信息

Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

出版信息

Eur Surg Res. 2022;63(3):123-131. doi: 10.1159/000519708. Epub 2021 Dec 3.

DOI:10.1159/000519708

PMID:34864732

Abstract

PURPOSE

This study investigated the antiadhesive effects of Mediclore®, rosuvastatin, and a combination of Mediclore and rosuvastatin in a rat adhesion model.

METHODS

The adhesion models (a total of 58 adult male rats) were divided into 4 groups. The control group (group C) received no special materials except for a saline. The experimental groups were treated with 5 mL of Mediclore (group M), rosuvastatin (group R), or rosuvastatin and Mediclore (group RM), and these materials were intraperitoneally placed under the incision. At postoperative day 14, the rats underwent re-laparotomy and adhesiolysis. Three investigators blinded to group assignment scored the extent of adhesion formation, the numbers of remote adhesions, and the extent of acute/chronic inflammation, fibrosis, edema, and congestion on resected specimens via histologic examination.

RESULTS

The macroscopic adhesion score in group RM (7.27 ± 3.51) was significantly lower than those in groups C (13.36 ± 2.24) and R (11.71 ± 1.98); group M (9.13 ± 4.09) had a significantly lower adhesion score than group C. The number of remote adhesions was significantly lower in groups R and RM than in group C. The acute inflammation score, chronic inflammation score, and fibrosis score in group RM; the acute inflammation score in group R; and the fibrosis score in group M were significantly lower than those in group C.

CONCLUSION

The intraperitoneal application of Mediclore and a combination of Mediclore and rosuvastatin effectively reduced postoperative adhesions.

摘要

目的

本研究旨在探讨 Mediclore®、瑞舒伐他汀以及 Mediclore 与瑞舒伐他汀联合使用在大鼠粘连模型中的抗粘连作用。

方法

将粘连模型（共 58 只成年雄性大鼠）分为 4 组。对照组（C 组）除生理盐水外未使用特殊材料。实验组分别给予 5 mL Mediclore（M 组）、瑞舒伐他汀（R 组）或瑞舒伐他汀和 Mediclore（RM 组），这些材料在切口下经腹腔内放置。术后第 14 天，大鼠再次行剖腹术和粘连松解术。3 名研究者在不了解分组的情况下，通过组织学检查对粘连形成程度、远处粘连数量以及切除标本的急性/慢性炎症、纤维化、水肿和充血程度进行评分。

结果

RM 组（7.27 ± 3.51）的宏观粘连评分明显低于 C 组（13.36 ± 2.24）和 R 组（11.71 ± 1.98）；M 组（9.13 ± 4.09）的粘连评分明显低于 C 组。R 组和 RM 组的远处粘连数量明显少于 C 组。RM 组的急性炎症评分、慢性炎症评分和纤维化评分；R 组的急性炎症评分；以及 M 组的纤维化评分明显低于 C 组。