Aslan Anolin, Aslan Cynthia, Zolbanin Naime Majidi, Jafari Reza
Department of Critical Care Nursing, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pneumonia (Nathan). 2021 Dec 6;13(1):14. doi: 10.1186/s41479-021-00092-9.
COVID-19 pandemic is a serious concern in the new era. Acute respiratory distress syndrome (ARDS), and lung failure are the main lung diseases in COVID-19 patients. Even though COVID-19 vaccinations are available now, there is still an urgent need to find potential treatments to ease the effects of COVID-19 on already sick patients. Multiple experimental drugs have been approved by the FDA with unknown efficacy and possible adverse effects. Probably the increasing number of studies worldwide examining the potential COVID-19 related therapies will help to identification of effective ARDS treatment. In this review article, we first provide a summary on immunopathology of ARDS next we will give an overview of management of patients with COVID-19 requiring intensive care unit (ICU), while focusing on the current treatment strategies being evaluated in the clinical trials in COVID-19-induced ARDS patients.
新冠疫情是新时代的一个严重关切问题。急性呼吸窘迫综合征(ARDS)和肺衰竭是新冠患者的主要肺部疾病。尽管现在已有新冠疫苗,但仍迫切需要找到潜在的治疗方法,以减轻新冠对已患病患者的影响。多种实验性药物已获美国食品药品监督管理局(FDA)批准,但其疗效未知且可能存在不良反应。全球范围内越来越多研究新冠相关潜在疗法的研究,可能有助于确定有效的ARDS治疗方法。在这篇综述文章中,我们首先概述ARDS的免疫病理学,接下来将概述需要重症监护病房(ICU)的新冠患者的管理,同时重点关注新冠诱导的ARDS患者临床试验中正在评估的当前治疗策略。