部分 EMT 率先引发癌症转移。
Partial EMT takes the lead in cancer metastasis.
机构信息
Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
出版信息
Dev Cell. 2021 Dec 6;56(23):3174-3176. doi: 10.1016/j.devcel.2021.11.012.
In this issue of Developmental Cell, Lüönd et al. developed a tracing system, using the uncharacterized early epithelial-mesenchymal transition (EMT)-marker Tenascin C, to monitor cells undergoing partial EMT during malignant mammary cancer progression. They find that partial, but not full, EMT contributes to metastasis and that full EMT contributes to chemoresistance.
在本期《发育细胞》中，Lüönd 等人开发了一种追踪系统，该系统使用尚未明确特征的早期上皮-间充质转化（EMT）标志物腱糖蛋白 C，来监测恶性乳腺癌进展过程中经历部分 EMT 的细胞。他们发现，部分 EMT（而非完全 EMT）有助于转移，而完全 EMT 则有助于化疗耐药。
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