Jaafar Adila Mohamad, Hasnu Norafida, Zainal Zulkarnain, Masarudin Mas Jaffri, Md Ajat Mohd Mokrish, Aung Min Min, Rayung Marwah
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Unit of Chemistry, Centre of Foundation Studies for Agriculture Science, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Polymers (Basel). 2021 Nov 27;13(23):4153. doi: 10.3390/polym13234153.
Recently, the antibacterial properties of Carvacrol (Carv) have been significantly reported. However, due to the unstable properties of Carv under various environment conditions, research approaches tailored towards its widespread and efficient use in various antimicrobial applications are scarce. Here, we discuss progress towards overcoming this challenge by utilising the encapsulation of Carv in gellan gum hydrogels to form thin films (GG-Carv) containing different concentrations of Carv (0.01-0.32 M). FTIR spectrum of GG-Carv revealed that both functional groups from GG and Carv existed. The carbon, hydrogen and nitrogen elemental analysis further supported the encapsulation of Carv with the changes in the element percentage of GG-Carv. Both swelling and degradation percentage increased with time and the decreasing patterns were observed as the concentration of Carv increased. In an antibacterial study, GG-Carv exhibited significant antibacterial activity against with the clear inhibition zone of 200 mm and the detection of bacterial growth showed enhancement with continuous decline throughout the study as compared to free-standing Carv.
最近，香芹酚（Carv）的抗菌特性已有大量报道。然而，由于香芹酚在各种环境条件下性质不稳定，针对其在各种抗菌应用中广泛有效使用的研究方法稀缺。在此，我们讨论通过将香芹酚封装在结冷胶水凝胶中以形成含有不同浓度香芹酚（0.01 - 0.32 M）的薄膜（GG - Carv）来克服这一挑战的进展。GG - Carv的傅里叶变换红外光谱显示，GG和Carv的官能团均存在。碳、氢和氮元素分析进一步支持了随着GG - Carv元素百分比的变化香芹酚被封装的情况。溶胀率和降解率均随时间增加，且随着香芹酚浓度的增加呈现下降趋势。在一项抗菌研究中，GG - Carv对[此处原文缺失具体细菌名称]表现出显著的抗菌活性，抑菌圈清晰，直径达200 mm，与游离香芹酚相比，整个研究过程中细菌生长检测显示随着时间持续下降，细菌生长受到抑制且抑制效果增强。
Zotero 插件
