Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 841 04 Bratislava, Slovakia.
Int J Mol Sci. 2021 Nov 23;22(23):12641. doi: 10.3390/ijms222312641.
The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found to accumulate with age and may contribute to age-related skin changes and pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on skin aging. By affecting molecular pathways of senescence, polyphenols are able to prevent or delay the senescence formation and, consequently, avoid or ameliorate aging and age-associated pathologies of the skin. This review aims to provide an overview of the current state of knowledge in skin aging and cellular senescence, and to summarize the recent in vitro studies related to the anti-senescent mechanisms of natural polyphenols carried out on keratinocytes, melanocytes and fibroblasts. Aged skin in the context of the COVID-19 pandemic will be also discussed.
皮肤作为人体的屏障器官，会持续受到各种刺激，从而影响其形态和功能。衰老细胞随着年龄的增长而积累，可能导致与年龄相关的皮肤变化和病理。天然多酚具有许多健康益处，包括对皮肤衰老的改善作用。多酚通过影响衰老的分子途径，能够预防或延迟衰老的形成，从而避免或改善皮肤衰老和与衰老相关的病理。本综述旨在概述皮肤衰老和细胞衰老的现有知识，并总结最近关于天然多酚在角质形成细胞、黑素细胞和成纤维细胞中抗衰老机制的体外研究。还将讨论 COVID-19 大流行背景下的老年皮肤。
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