核仁无序蛋白的相分离与定位和功能有关。
Phase Separation of Intrinsically Disordered Nucleolar Proteins Relate to Localization and Function.
机构信息
Biochemistry and Molecular Plant Biology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, Mexico.
Biotechnology Department, Centro de Investigación Científica de Yucatán A.C., Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida C.P. 97200, Yucatán, Mexico.
出版信息
Int J Mol Sci. 2021 Dec 3;22(23):13095. doi: 10.3390/ijms222313095.
The process of phase separation allows for the establishment and formation of subcompartmentalized structures, thus enabling cells to perform simultaneous processes with precise organization and low energy requirements. Chemical modifications of proteins, RNA, and lipids alter the molecular environment facilitating enzymatic reactions at higher concentrations in particular regions of the cell. In this review, we discuss the nucleolus as an example of the establishment, dynamics, and maintenance of a membraneless organelle with a high level of organization.
相分离过程允许建立和形成亚区隔结构，从而使细胞能够以精确的组织和低能量需求同时进行多个过程。蛋白质、RNA 和脂质的化学修饰改变了分子环境，有利于在细胞的特定区域以更高的浓度进行酶反应。在这篇综述中，我们以核仁为例讨论了无膜细胞器的建立、动态和维持，以及其高度的组织化水平。
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