• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

美国公共卫生应对日益恶化的阿片类药物危机的方法呼吁采取减少伤害策略,以减轻阿片类药物成瘾和过量死亡造成的伤害。

The Public Health Approach to the Worsening Opioid Crisis in the United States Calls for Harm Reduction Strategies to Mitigate the Harm From Opioid Addiction and Overdose Deaths.

机构信息

Immigration and Customs Enforcement Health Service Corps, U.S. Public Health Service, Washington, DC 20536, USA.

Federal Bureau of Prisons, U.S. Public Health Service, Danbury, CT 06811, USA.

出版信息

Mil Med. 2022 Aug 25;187(9-10):244-247. doi: 10.1093/milmed/usab485.

DOI:10.1093/milmed/usab485
PMID:34908134
Abstract

The opioid crisis has devastated the U.S. more than any other country, and the epidemic is getting worse. While opioid prescriptions have decreased by more than 40% from its peak in 2010, unfortunately, opioid-related overdose deaths have not declined but continued to increase. With greater scrutiny on prescription opioids, many users switched to the cheaper and more readily available heroin that drove up heroin-related overdose deaths from 2010 to peak in 2016, being overtaken by the spike in synthetic opioid (mostly fentanyl)-related overdose deaths. The surge in fentanyl-related overdose deaths since 2013 is alarming as fentanyl is more potent and deadly. One thing is certain the opioid crisis is not improving but has become dire with the surge in fentanyl-related overdose deaths. Evidence-based strategies have to be implemented in the U.S. to control this epidemic before it destroys more lives. Other countries, including European countries and Canada, have invested more in harm reduction strategies than the U.S. even though they (especially Europe) do not face anywhere near the level of crisis as the U.S. In the long-run, upstream measures (tackling the social determinants of health) are more effective public health strategies to control the epidemic. In the meantime, however, harm reduction strategies have to be employed to mitigate the harm from addiction and overdose deaths.

摘要

阿片类药物危机对美国的打击比任何其他国家都严重,而且这种流行病还在恶化。虽然阿片类药物处方量从 2010 年的峰值下降了 40%以上,但不幸的是,阿片类药物相关的过量死亡人数并没有下降,反而继续上升。随着对处方类阿片类药物的审查更加严格,许多使用者转而使用更便宜、更容易获得的海洛因,这导致了 2010 年至 2016 年海洛因相关过量死亡人数的上升,并超过了合成类阿片(主要是芬太尼)相关过量死亡人数的上升。自 2013 年以来,芬太尼相关过量死亡人数的激增令人震惊,因为芬太尼的效力和致命性更强。有一件事是肯定的,阿片类药物危机并没有改善,反而因为芬太尼相关过量死亡人数的激增而变得更加严重。美国必须实施基于证据的策略来控制这一流行病,否则它将摧毁更多的生命。包括欧洲国家和加拿大在内的其他国家在减少伤害策略上的投入比美国更多,尽管它们(尤其是欧洲)面临的危机程度远不及美国。从长远来看,上游措施(解决健康的社会决定因素)是控制这一流行病的更有效的公共卫生策略。然而,在这期间,必须采用减少伤害策略来减轻成瘾和过量死亡带来的危害。

相似文献

1
The Public Health Approach to the Worsening Opioid Crisis in the United States Calls for Harm Reduction Strategies to Mitigate the Harm From Opioid Addiction and Overdose Deaths.美国公共卫生应对日益恶化的阿片类药物危机的方法呼吁采取减少伤害策略,以减轻阿片类药物成瘾和过量死亡造成的伤害。
Mil Med. 2022 Aug 25;187(9-10):244-247. doi: 10.1093/milmed/usab485.
2
Reframing the Prevention Strategies of the Opioid Crisis: Focusing on Prescription Opioids, Fentanyl, and Heroin Epidemic.重新构建阿片类药物危机的预防策略:聚焦处方阿片类药物、芬太尼和海洛因流行。
Pain Physician. 2018 Jul;21(4):309-326.
3
Is Europe Facing an Emerging Opioid Crisis Comparable to the U.S.?欧洲是否面临与美国类似的新兴阿片类药物危机?
Ther Drug Monit. 2021 Feb 1;43(1):42-51. doi: 10.1097/FTD.0000000000000789.
4
Losing the uphill battle? Emergent harm reduction interventions and barriers during the opioid overdose crisis in Canada.在加拿大阿片类药物过量危机期间,错失这场艰难斗争的胜利?紧急减少危害干预措施和障碍。
Int J Drug Policy. 2019 Sep;71:178-182. doi: 10.1016/j.drugpo.2019.02.005. Epub 2019 Apr 8.
5
The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies.非法芬太尼使用、过量用药的不断加剧的危机,以及潜在的治疗策略。
Transl Psychiatry. 2019 Nov 11;9(1):282. doi: 10.1038/s41398-019-0625-0.
6
Fentanyl harm reduction strategies among Latinx communities in the United States: a scoping review.美国拉丁裔群体中芬太尼的危害减少策略:范围综述。
Harm Reduct J. 2024 Aug 16;21(1):150. doi: 10.1186/s12954-024-01070-2.
7
The Opioid Crisis: Prevalence and Markets of Opioids.阿片类药物危机:阿片类药物的流行和市场。
Forensic Sci Rev. 2022 Jan;34(1):43-70.
8
Guidance for Handling the Increasing Prevalence of Drugs Adulterated or Laced With Fentanyl.处理芬太尼掺杂或添加药物日益流行的指南。
Psychiatr Serv. 2023 Oct 1;74(10):1059-1062. doi: 10.1176/appi.ps.202100660. Epub 2023 Apr 12.
9
Exposure to fentanyl-contaminated heroin and overdose risk among illicit opioid users in Rhode Island: A mixed methods study.罗德岛非法阿片类药物使用者中接触受芬太尼污染的海洛因与过量用药风险:一项混合方法研究。
Int J Drug Policy. 2017 Aug;46:136-145. doi: 10.1016/j.drugpo.2017.05.023. Epub 2017 Jun 1.
10
Drug checking as a potential strategic overdose response in the fentanyl era.药物检测作为芬太尼时代潜在的战略过量应对措施。
Int J Drug Policy. 2018 Dec;62:59-66. doi: 10.1016/j.drugpo.2018.10.001. Epub 2018 Oct 22.

引用本文的文献

1
Opioid Use Disorder Significantly Increases Complications and Costs in Primary and Revision Total Knee Arthroplasty a Nationwide Analysis and the Case for Preoperative Screening.阿片类药物使用障碍显著增加初次和翻修全膝关节置换术的并发症及成本:一项全国性分析及术前筛查的理由
J Clin Med. 2025 May 29;14(11):3832. doi: 10.3390/jcm14113832.
2
A systematic review of macro-, meso, and micro-level harm reduction interventions addressing the U.S. opioid overdose epidemic.一项针对美国阿片类药物过量流行问题的宏观、中观和微观层面减少伤害干预措施的系统综述。
Drugs (Abingdon Engl). 2025;32(1):1-14. doi: 10.1080/09687637.2024.2306826. Epub 2024 Jan 23.
3
Developing predictive models for µ opioid receptor binding using machine learning and deep learning techniques.
使用机器学习和深度学习技术开发μ阿片受体结合的预测模型。
Exp Biol Med (Maywood). 2025 Mar 19;250:10359. doi: 10.3389/ebm.2025.10359. eCollection 2025.
4
The resurgence of synthetic cannabinoid receptor agonists as adulterants in the Era of Cannabis legalization: Lessons from prior epidemics and clinical implications.大麻合法化时代合成大麻素受体激动剂作为掺假物的再度出现:既往流行事件的教训及临床意义
Neurosci Biobehav Rev. 2025 Mar;170:106043. doi: 10.1016/j.neubiorev.2025.106043. Epub 2025 Feb 6.
5
Network Analysis of Medical Claims Data Suggests Network-Based, Regional Targeting and Intervention Delivery Strategies to Increase Access to Office Based Opioid Treatment (OBOT) for Opioid Use Disorder (OUD).医疗索赔数据分析网络提示以网络为基础的区域性目标定位和干预传递策略,以增加获得基于办公室的阿片类药物治疗(OBOT)治疗阿片类药物使用障碍(OUD)的机会。
Inquiry. 2024 Jan-Dec;61:469580241238422. doi: 10.1177/00469580241238422.
6
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal.抗抑郁药阿戈美拉汀可减弱吗啡诱导的复吸,但对自我给药或急性戒断无影响。
Pharmacol Biochem Behav. 2023 Feb;223:173525. doi: 10.1016/j.pbb.2023.173525. Epub 2023 Feb 8.
7
Fentanyl Induces Novel Conditioned Place Preference in Adult Zebrafish, Disrupts Neurotransmitter Homeostasis, and Triggers Behavioral Changes.芬太尼诱导成年斑马鱼产生新的条件性位置偏好,破坏神经递质平衡,并引发行为改变。
Int J Environ Res Public Health. 2022 Oct 19;19(20):13533. doi: 10.3390/ijerph192013533.