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纳米银医用抗菌敷料联合高流量氧疗促进浅表恶性肿瘤溃疡创面愈合

Nano-Silver Medical Antibacterial Dressing Combined with High-Flow Oxygen Therapy Facilitates Ulcer Wound Healing of Superficial Malignant Tumors.

作者信息

Yu Dan, Yang Di-Xiao, Li Yao, Guan Bi, Ming Qian, Li Yan, Zhu Yi-Ping, Chen Li-Qing, Luo Wei-Xiang

机构信息

Department of Otolaryngology and Hepatobiliary, Chengdu Fifth People's Hospital, Chengdu, 611130, Sichuan, People's Republic of China.

Nursing Department, Chengdu Fifth People's Hospital, Chengdu, 611130, Sichuan, People's Republic of China.

出版信息

Cancer Manag Res. 2021 Dec 6;13:9007-9013. doi: 10.2147/CMAR.S341448. eCollection 2021.

Abstract

BACKGROUND

Due to the poor healing of superficial malignant tumor ulcer wounds, patients suffer great pain and significantly reduced quality of life. Related research shows that oxygen therapy can reduce wound bleeding and promote wound healing.

OBJECTIVE

This study aims to explore the therapeutic effect of nano-silver antibacterial dressing combined with high-flow oxygen therapy on surface malignant tumor ulcers.

METHODS

In this retrospective analysis, 64 patients with superficial malignant tumors and ulcer infection were included and divided into the research group and the control group, with 32 cases in each group. After conventional debridement, the control group was treated with vaseline dressing, while the research group was treated with nano-silver medical antibacterial dressing combined with high-flow oxygen therapy. Both groups were treated for 7 days. The frequency of dressing change and the number of times of blood oozing between the two groups after treatment were recorded. The pain, clinical efficacy, and levels of procalcitonin (PCT) and C-reactive protein (CRP) were compared between the two groups before and after treatment.

RESULTS

The dressing changes and blood oozing were less frequent in the research group compared with the control group. The pain score and the levels of PCT and CRP in the research group were lower than those in the control group. The overall response rate was significantly higher in the research group as compared to the control group. All the above differences were statistically significant (P<0.05).

CONCLUSION

Nano-silver medical antibacterial dressing combined with high-flow oxygen therapy can reduce the frequency of dressing changes in patients, relieve pain, reduce inflammation, and accelerate the healing of superficial malignant tumor ulcer wounds.

摘要

背景

由于浅表恶性肿瘤溃疡创面愈合不佳,患者承受巨大痛苦,生活质量显著下降。相关研究表明,氧疗可减少创面出血并促进创面愈合。

目的

本研究旨在探讨纳米银抗菌敷料联合高流量氧疗对体表恶性肿瘤溃疡的治疗效果。

方法

本回顾性分析纳入64例浅表恶性肿瘤合并溃疡感染患者,分为研究组和对照组,每组32例。常规清创后,对照组采用凡士林纱布换药,研究组采用纳米银医用抗菌敷料联合高流量氧疗。两组均治疗7天。记录两组治疗后换药频率及渗血次数。比较两组治疗前后的疼痛程度、临床疗效及降钙素原(PCT)和C反应蛋白(CRP)水平。

结果

与对照组相比,研究组换药及渗血次数较少。研究组疼痛评分、PCT及CRP水平低于对照组。研究组总有效率显著高于对照组。上述差异均有统计学意义(P<0.05)。

结论

纳米银医用抗菌敷料联合高流量氧疗可减少患者换药频率,缓解疼痛,减轻炎症,加速浅表恶性肿瘤溃疡创面愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1e/8664651/c1330080472d/CMAR-13-9007-g0001.jpg

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