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从母体子宫到“子宫装置”?对部分外胚层发生的伦理和科学考虑。

From the maternal uterus to the "uterus device"? Ethical and scientific considerations on partial ectogenesis.

机构信息

Department of Anatomical, Histological, Forensic, and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Dec;25(23):7354-7362. doi: 10.26355/eurrev_202112_27429.

Abstract

The article aims to elaborate the progress made in partial ectogenesis research on sheep as well as human embryos. Since the ban on embryos experimentation after the 14-day window is a major roadblock in terms of partial ectogenesis research, the authors have weighed the possibility that such a ban could be reconsidered. In favor of easing such a restriction, it may be argued that: (a) unlike the Catholic approach, prevalent ethics precepts hold that the embryo's interest ought to be balanced against the interests of the other parties involved; (b) an extension of the 14-day deadline would no longer make ethically untenable practices acceptable; hence, the "slippery slope" argument, although generally worthy, would not conclusively apply to partial ectogenesis; (c) in mainstream embryo research efforts, there is a conflict between the lives of embryos and the health of individuals already born; as for partial ectogenesis, however, such a conflict would be between the lives of embryos and the lives of fetuses which would not survive otherwise. Still, in light of the embryo's status as a human being, the authors conclude that such research practices should only be allowed on supernumerary embryos.

摘要

本文旨在阐述羊和人类胚胎部分外生性研究取得的进展。由于在 14 天窗口期之后禁止胚胎实验是部分外生性研究的主要障碍,作者权衡了重新考虑这一禁令的可能性。为了放宽这种限制,可以认为:(a)与天主教的方法不同,普遍的伦理原则认为,胚胎的利益应该与其他相关方的利益相平衡;(b)延长 14 天的最后期限将不再使在伦理上站不住脚的做法变得可以接受;因此,虽然“滑坡”论点通常是有价值的,但它不会对部分外生性研究具有决定性的影响;(c)在主流胚胎研究工作中,胚胎的生命与已经出生的个人的健康之间存在冲突;而对于部分外生性研究,这种冲突将是在胚胎的生命与否则无法存活的胎儿的生命之间。尽管如此,鉴于胚胎作为人类的地位,作者认为这种研究实践应该只允许在多余的胚胎上进行。

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