抗核抗体呈斑点型患者的临床和实验室特征

Clinical and laboratory characteristics of patients with speckled pattern antinuclear antibodies.

作者信息

McMillan S A, Fay A C, Taggart A J, McCrea J D, Roberts S D, Boyd M W, Nelson J K, Haire M

出版信息

Ulster Med J. 1986 Oct;55(2):112-7.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2448365/

Abstract

Fifty patients whose sera contained a speckled antinuclear antibody (ANA) were interviewed and examined to determine if there was any relationship between their clinical manifestations and the presence of certain serological markers. The results suggest that speckled ANA is usually found in patients with definite connective tissue diseases, but a significant minority have incomplete or early stages of these diseases. Characterisation of the antibody to extractable nuclear antigen (ENA) and other serological markers does not normally assist in making a clinical diagnosis, but the detection of a speckled ANA should prompt further investigation and careful follow-up.

摘要

对50名血清中含有斑点型抗核抗体（ANA）的患者进行了访谈和检查，以确定其临床表现与某些血清学标志物的存在之间是否存在任何关联。结果表明，斑点型ANA通常见于患有明确结缔组织病的患者，但有相当少数患者处于这些疾病的不完全或早期阶段。对可提取核抗原（ENA）抗体和其他血清学标志物的鉴定通常无助于做出临床诊断，但检测到斑点型ANA应促使进一步调查并进行仔细随访。

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