评估 T-SPOT.TB 试验、氧化相关因素和抗菌肽 LL-37 在 2 型糖尿病合并肺结核中的诊断价值。
Evaluation of the T-SPOT.TB test, oxidation-related factors, and antimicrobial peptide LL-37 in the diagnosis of pulmonary tuberculosis with type 2 diabetes.
机构信息
Department of Infectious Diseases, Beijing Geriatric Hospital, Beijing, China.
Department of Clinical Laboratory, 517575Beijing Geriatric Hospital, Beijing Geriatric Hospital, Beijing, China.
出版信息
J Int Med Res. 2021 Dec;49(12):3000605211064418. doi: 10.1177/03000605211064418.
OBJECTIVE
To investigate the diagnostic value of the T cell spot (T-SPOT.TB) test, oxidation-related factors (ORF), and antimicrobial peptide LL-37 in patients with pulmonary tuberculosis (PTB) with type 2 diabetes.
METHODS
A total of 560 patients with PTB admitted to our hospital from January 2019 to April 2021 were retrospectively included in this study. Of these, 232 patients with PTB and type 2 diabetes were assigned to the combined group, and 328 patients without complications were assigned to the PTB group.
RESULTS
Areas under the curve (AUCs) for the number of spot-forming cells in CFP10 and ESAT-6 test panels detecting PTB with type 2 diabetes were 0.892 (95% confidence interval [CI] 0.831-0.921) and 0.893 (95% CI 0.841-0.935), respectively. CFP10 combined with ESAT-6 had the highest diagnostic value, with sensitivity and specificity levels and an AUC of 87.73%, 88.93%, and 0.942 (95% CI 0.907-0.967), respectively. The levels of total antioxidant capacity, superoxide dismutase, and catalase in the combined group were lower than in PTB and control groups.
CONCLUSION
The combination of T-SPOT.TB, ORF, and LL-37 in the diagnosis of pulmonary tuberculosis with type 2 diabetes mellitus has a high diagnostic value and clinical application value.
目的
探讨 T 细胞斑点（T-SPOT.TB）试验、氧化相关因子（ORF）和抗菌肽 LL-37 在合并 2 型糖尿病肺结核（PTB）患者中的诊断价值。
方法
回顾性分析 2019 年 1 月至 2021 年 4 月我院收治的 560 例 PTB 患者的临床资料，其中合并 2 型糖尿病患者 232 例纳入联合组，单纯 PTB 患者 328 例纳入 PTB 组。
结果
CFP10 和 ESAT-6 试验检测合并 2 型糖尿病肺结核的斑点形成细胞数的曲线下面积（AUC）分别为 0.892（95%可信区间：0.8310.921）和 0.893（95%可信区间：0.8410.935）。CFP10 联合 ESAT-6 检测具有最高的诊断价值，其敏感性、特异性和 AUC 分别为 87.73%、88.93%和 0.942（95%可信区间：0.907~0.967）。联合组总抗氧化能力、超氧化物歧化酶和过氧化氢酶水平均低于 PTB 组和对照组。
结论
T-SPOT.TB、ORF 和 LL-37 联合检测在诊断合并 2 型糖尿病肺结核中具有较高的诊断价值和临床应用价值。
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