Shi Yanni, Zhang Kezhong, Ye Ming
School of Stomatology, Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Dec 16;17:3705-3714. doi: 10.2147/NDT.S336939. eCollection 2021.
The relationship between the risk of Parkinson disease and well-water consumption has been extensively studied, but the results have been contradictory. Therefore, we conducted a meta-analysis of observational studies to systematically assess the relationship between well-water consumption and Parkinson disease risk.
We followed the PRISMA checklist in completing the meta-analysis. We searched two electronic databases (PubMed, EBSCO, EMBASE and Cochrane) from establishment to October, 2021, to identify relevant studies linking well-water drinking to Parkinson risk. We used a random-effects model to calculate the overall odds ratio (OR) with 95% confidence interval (CI). To reduce intragroup heterogeneity, we conducted subgroup analyses according to the research design and geographic area.
After careful review, a total of 15 case-control-designed studies included data suitable for our meta-analysis. The total number of cases and total controls that contribute to the combined OR were 2182 and 2456. The combined OR for ever well-water drinkers versus non-drinkers was 1.16 (95% CI: 0.97-1.39, I = 44.52%). In subgroup analysis by geographic area, a significant association was observed in studies conducted in Asia (OR 1.29, 95% CI: 1.05-1.58, I = 0.0%, p for heterogeneity = 0.460) but not in studies conducted in America (OR 0.97, 95% CI: 0.76-1.24, I = 41.2%, p for heterogeneity = 0.164). In subgroup analysis by study design, a borderline significant association emerged in hospital-based case-control studies (OR 1.31, 95% CI: 1.04-1.65, I = 40.9%, p for heterogeneity = 0.118) but not in population-based case-control studies (OR 0.96, 95% CI: 0.73-1.26, I = 41.1%, p for heterogeneity = 0.165).
Our results indicate that there is no significant correlation between well-water consumption and PD risk.
帕金森病风险与饮用井水之间的关系已得到广泛研究，但结果相互矛盾。因此，我们进行了一项观察性研究的荟萃分析，以系统评估饮用井水与帕金森病风险之间的关系。
我们按照PRISMA清单完成荟萃分析。我们检索了两个电子数据库（PubMed、EBSCO、EMBASE和Cochrane），从建库至2021年10月，以确定将饮用井水与帕金森病风险相关联的相关研究。我们使用随机效应模型计算总体比值比（OR）及95%置信区间（CI）。为减少组内异质性，我们根据研究设计和地理区域进行了亚组分析。
经过仔细审查，共有15项病例对照设计研究纳入了适合我们荟萃分析的数据。纳入合并OR的病例总数和对照总数分别为2182例和2456例。曾经饮用井水者与未饮用者的合并OR为1.16（95%CI：0.97 - 1.39，I² = 44.52%）。在按地理区域进行的亚组分析中，在亚洲进行的研究中观察到显著关联（OR 1.29，95%CI：1.05 - 1.58，I² = 0.0%，异质性p值 = 0.460），但在美国进行的研究中未观察到（OR 0.97，95%CI：0.76 - 1.24，I² = 41.2%，异质性p值 = 0.164）。在按研究设计进行的亚组分析中，基于医院的病例对照研究出现了临界显著关联（OR 1.31，95%CI：1.04 - 1.65，I² = 40.9%，异质性p值 = 0.118），但在基于人群的病例对照研究中未出现（OR 0.96，95%CI：0.73 - 1.26，I² = 41.1%，异质性p值 = 0.165）。
我们的结果表明，饮用井水与帕金森病风险之间无显著相关性。
Zotero 插件
