Boccella Mariarosaria, Santella Biagio, Pagliano Pasquale, De Filippis Anna, Casolaro Vincenzo, Galdiero Massimiliano, Borrelli Anna, Capunzo Mario, Boccia Giovanni, Franci Gianluigi
Department of Laboratory and Infectious Disease Sciences, Agostino Gemelli University Hospital IRCCS, 00168 Rome, Italy.
Section of Microbiology and Virology, University Hospital "Luigi Vanvitelli", 80138 Naples, Italy.
Antibiotics (Basel). 2021 Dec 19;10(12):1552. doi: 10.3390/antibiotics10121552.
Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent years, among the multidrug-resistant microorganisms responsible for nosocomial infections, the species have received much attention. Indeed, have peculiar skills in their ability to acquire resistance genes and to cause severe diseases, such as endocarditis. This study showed the prevalence and antimicrobial resistance rate of spp. isolated from clinical samples, from January 2015 to December 2019 at the University Hospital "San Giovanni di Dio e Ruggi d'Aragona" in Salerno, Italy. A total of 3236 isolates of (82.2%) and (17.8%) were collected from urine cultures, blood cultures, catheters, respiratory tract, and other samples. Bacterial identification and antibiotic susceptibility were performed with VITEK 2. showed a high resistance rate against ampicillin (84.5%), ampicillin/sulbactam (82.7%), and imipenem (86.7%), while showed the highest resistance rate against gentamicin and streptomycin high level, but both were highly sensitive to such antibiotics as tigecycline and vancomycin. Studies of surveillance are an important tool to detect changes in the resistance profiles of the main pathogens. These antimicrobial susceptibility patterns are necessary to improve the empirical treatment guideline of infections.
抗菌药物耐药性是健康生态系统面临的主要威胁之一。近年来,在引起医院感染的多重耐药微生物中,该物种受到了广泛关注。事实上,它们在获取耐药基因和引发严重疾病(如心内膜炎)方面具有独特的能力。本研究显示了2015年1月至2019年12月期间,从意大利萨勒诺的“圣乔瓦尼迪奥·埃鲁吉·德阿罗纳”大学医院临床样本中分离出的某物种的流行率和抗菌药物耐药率。共从尿培养、血培养、导管、呼吸道及其他样本中收集到3236株某菌(82.2%)和另一菌(17.8%)。使用VITEK 2进行细菌鉴定和抗生素敏感性检测。某菌对氨苄西林(84.5%)、氨苄西林/舒巴坦(82.7%)和亚胺培南(86.7%)显示出较高的耐药率,而另一菌对庆大霉素和高水平链霉素显示出最高的耐药率,但两者对替加环素和万古霉素等抗生素均高度敏感。监测研究是检测主要病原体耐药谱变化的重要工具。这些抗菌药物敏感性模式对于改进感染的经验性治疗指南是必要的。