Zhou Yan-Xi, Zhang Hong, Peng Cheng
State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Library, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2021 Dec 7;12:771793. doi: 10.3389/fphar.2021.771793. eCollection 2021.
Puerarin, an isoflavone glycoside derived from (Willd.) Ohwi, has been identified as a pharmacologically active component with diverse benefits. A large number of experimental and clinical studies have demonstrated that puerarin is widely used in the treatment of a variety of diseases. Among them, cardiovascular diseases (CVDs) are the leading cause of death in the world, and therefore remain one of the most prominent global public health concerns. In this review, we systematically analyze the preclinical investigations of puerarin in CVDs, such as atherosclerosis, cardiac hypertrophy, heart failure, diabetic cardiovascular complications, myocardial infarction, stroke and hypertension. In addition, the potential molecular targets of puerarin are also discussed. Furthermore, we summarize the clinical trails of puerarin in the treatment of CVDs. Finally, the therapeutic effects of puerarin derivatives and its drug delivery systems are overviewed.
葛根素是一种从野葛（Willd.）Ohwi中提取的异黄酮苷，已被确定为具有多种益处的药理活性成分。大量实验和临床研究表明，葛根素广泛用于治疗多种疾病。其中，心血管疾病（CVDs）是全球主要死因，因此仍然是最突出的全球公共卫生问题之一。在本综述中，我们系统分析了葛根素在心血管疾病（如动脉粥样硬化、心肌肥大、心力衰竭、糖尿病心血管并发症、心肌梗死、中风和高血压）方面的临床前研究。此外，还讨论了葛根素潜在的分子靶点。此外，我们总结了葛根素治疗心血管疾病的临床试验。最后，概述了葛根素衍生物及其药物递送系统的治疗效果。
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