CHRNA2：米色脂肪体温调节和代谢的新范例。
CHRNA2: a new paradigm in beige thermoregulation and metabolism.
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Trends Cell Biol. 2022 Jun;32(6):479-489. doi: 10.1016/j.tcb.2021.11.009. Epub 2021 Dec 21.
The contribution of thermogenic adipocytes to maintain systemic metabolic homeostasis has been increasingly appreciated in recent years. It is now recognized that different types (e.g., brown, beige) and subtypes of thermogenic adipocytes may arise from various developmental origins. In addition to the adrenergic pathway, other signals can activate thermogenesis, including paracrine communication between immune cells within the adipose tissue niche and thermogenic adipocytes. In this opinion article we highlight the recently discovered beige-selective signaling between acetylcholine from immune cells and cholinergic receptor nicotinic alpha 2 subunit (CHRNA2) in activated beige adipocytes. We present our current knowledge of how this previously unrecognized adipose non-neuronal cholinergic signaling pathway mediates beige thermoregulation, and discuss its impact on whole-body fitness and its therapeutic potential as a novel target for combating metabolic disease.
近年来，产热脂肪细胞在维持全身代谢稳态方面的作用受到了越来越多的关注。现在人们已经认识到，不同类型（如棕色、米色）和亚型的产热脂肪细胞可能来自不同的发育起源。除了肾上腺素能途径外，其他信号也可以激活产热，包括脂肪组织龛位内免疫细胞与米色脂肪细胞之间的旁分泌通讯。在这篇观点文章中，我们强调了最近发现的免疫细胞乙酰胆碱与激活的米色脂肪细胞中烟碱型乙酰胆碱受体α2 亚单位（CHRNA2）之间的米色选择性信号。我们介绍了目前对于这种以前未被识别的脂肪非神经元胆碱能信号通路如何介导米色脂肪的体温调节的认识，并讨论了其对全身健康的影响及其作为治疗代谢性疾病的新靶点的潜在治疗意义。
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