克罗恩病患者的妊娠相关性乳腺癌：两例病例报告。

Gestational breast cancer in a patient with Crohn's disease: two case reports.

机构信息

Faculty of Medicine, Damascus University, Fayez Mansour Street, P. O. Box: 222, Damascus, Syria.

Department of Oncology, Al-Bairouni University Hospital, Damascus University, Harasta M5, Damascus, Syria.

出版信息

J Med Case Rep. 2021 Dec 27;15(1):633. doi: 10.1186/s13256-021-03224-3.

DOI:10.1186/s13256-021-03224-3

PMID:34961553

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8711207/

Abstract

BACKGROUND

Diagnosis of breast cancer during gestation is a rare occurrence. In addition, the diagnosis of breast cancer in a patient with Crohn's disease is not common. We present a rare case of gestational breast cancer in a patient with Crohn's disease, with a concurrent breast cancer diagnosis in her sister.

CASE PRESENTATION

A 31-year-old Syrian woman with Crohn's disease was diagnosed with breast cancer at 30 weeks gestation; she received neoadjuvant chemotherapy during gestation. Incidentally, her 37-year-old sister was also diagnosed concomitantly with breast cancer. Both sisters underwent and successfully completed surgery and adjuvant therapy. At a 5-year review, both patients showed no signs of recurrence. The Crohn's disease symptoms have also improved after chemotherapy, and the baby born after gestational chemotherapy is currently 5 years old with normal psychomotor development and without any congenital malformations.

CONCLUSIONS

This case report highlights the impact of gestation on breast cancer outcomes, the possibility of giving chemotherapy during gestation, and the effect of chemotherapy on the symptoms of Crohn's disease.

摘要

背景

妊娠期乳腺癌的诊断较为罕见。此外，在患有克罗恩病的患者中诊断乳腺癌也并不常见。我们报告了一例克罗恩病患者合并妊娠期乳腺癌的罕见病例，其姐姐也同时被诊断出患有乳腺癌。

病例介绍

一名 31 岁的叙利亚女性患有克罗恩病，在妊娠 30 周时被诊断患有乳腺癌；她在妊娠期接受了新辅助化疗。巧合的是，她 37 岁的姐姐也同时被诊断出患有乳腺癌。两姐妹均接受并成功完成了手术和辅助治疗。在 5 年的随访中，两位患者均未出现复发迹象。化疗后，克罗恩病的症状也有所改善，在妊娠期化疗后出生的婴儿目前 5 岁，精神运动发育正常，无任何先天畸形。