塔拉唑菌素 A 和塔拉唑异香豆素 A，海洋源真菌 sp. ZZ1616 的新代谢产物。
Talaromydien a and talaroisocoumarin A, new metabolites from the marine-sourced fungus sp. ZZ1616.
机构信息
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
出版信息
Nat Prod Res. 2022 Jan;36(1):460-465. doi: 10.1080/14786419.2020.1779265. Epub 2020 Jun 17.
New talaromydien A and talaroisocoumarin A (), together with nine known compounds (-), were isolated from a culture of the marine-derived sp. ZZ1616 in potato dextrose broth medium. Structures of the new compounds were elucidated based on their HRESIMS data, NMR spectroscopic analyses, the modified Mosher's method, ECD, C NMR and optical rotation calculations. Talaroisocoumarin A showed antimicrobial activities with MIC values of 36.0 μg/mL against methicillin-resistant , 32.0 μg/mL against , and 26.0 μg/mL against .
新型塔拉唑米定 A 和塔拉唑异香豆素 A（）与另外 9 种已知化合物（-）一起从海洋来源的 sp. ZZ1616 的培养物中分离得到。基于高分辨质谱数据、NMR 谱分析、改进的莫舍尔法、ECD、13C NMR 和旋光计算，确定了新化合物的结构。塔拉唑异香豆素 A 显示出抗菌活性，对耐甲氧西林的 MIC 值为 36.0μg/mL，对 32.0μg/mL，对 26.0μg/mL。
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