Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathobiology & Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Biosens Bioelectron. 2022 Mar 15;200:113924. doi: 10.1016/j.bios.2021.113924. Epub 2021 Dec 30.
In a published review entitled "COVID-19 diagnosis -A review of current methods", the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome structure. However, according to the scientific evidence, among coronaviruses only some betacoronaviruses (Embecovirus subgenera) contain HE, and the genome of most of the coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV lack the HE gene. In addition, the genome of SARS-CoV-2 contains several accessory proteins ORFs including ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c, and ORF10.
在一篇题为“COVID-19 诊断-当前方法综述”的已发表评论中，作者认为血凝素酯酶是 SARS-CoV-2 的结构蛋白之一，并且他们没有在 SARS-CoV-2 基因组结构中表示 ORF3b、ORF9b 和 ORF9c。然而，根据科学证据，在冠状病毒中，只有一些贝塔冠状病毒（Embecovirus 亚属）含有 HE，而大多数冠状病毒的基因组，如 SARS-CoV-2、SARS-CoV 和 MERS-CoV 缺乏 HE 基因。此外，SARS-CoV-2 的基因组包含几个辅助蛋白 ORFs，包括 ORF3a、ORF3b、ORF6、ORF7a、ORF7b、ORF8、ORF9b、ORF9c 和 ORF10。
