Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Signal Transduct Target Ther. 2022 Jan 3;7(1):3. doi: 10.1038/s41392-021-00762-6.
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
Wnt/β-catenin 通路由一组在胚胎发育和成人组织稳态中发挥关键作用的蛋白组成。Wnt/β-catenin 信号的失调通常会导致各种严重疾病，包括癌症和非癌症疾病。尽管许多文章已经从不同方面综述了 Wnt/β-catenin，但缺乏对肿瘤和疾病中 Wnt/β-catenin 信号通路的起源、组成、功能和临床试验进行系统综述。在本文中，我们结合最新研究，从上述五个方面全面综述了 Wnt/β-catenin 通路。最后，我们针对针对疾病治疗中 Wnt 信号通路的小分子化合物的发展提出了挑战和机遇。
